high yield Flashcards
coagulase on ?
S. aureus
TSST uses ___?
super antigens
Glycocalyx on?
Staph epidermis
Strep pyogen has _ protein
M
M protein on ?
Strep - pryogenes
Who has antiphagocytic polysaccarhides capsule
strep pneumoniae
3 main causes of endocaridits bugs
S. aureus, Coagulase negative staph (so basically all staph)
Strep viridan
Rheumatic heart disease from which bug?
Strep pygoens (strep)
Dextran made by ?
viridans streptococci
Classify N. gonorrhoeae
Gram neg, diplo-cocci
Drug enter CSF
cephalosporin 3/4 Metronidzaole Chloroamphenicol Sulfoamides/trimethoprim Rifampin
Drug enter CSF with inflammation
vanco
penicillin
ciprofloxacin
Tetracycline
Drug enter CSF Poor
Aminoglycosides
Cephalosporin 1/2
erythromycin
clindamycin
Drugs fetus/pregnancy
aminoglycosides, variconazole, metronidazole, chloroamphenicol, tetracycline, fluoroquinolone
Bone accumulation
Clindamycin
accumulation lungs
macrolides
accumulation peridonitis/acne
tetracyclines
UTI accumulation
Nitrofurantonin
accumulation 8th nerve/renal
aminoglycosides
accumulation in bone/teeth bad
tetracycline in kids
B-ALL markers
CD19, CD22, CD79a
NO CD20/surface IgX (not mature)
T-ALL markers
CD2, 3, 7
CD4/8
CD99, CD1a
ALL general markers
CD34, TdT
HLA-DR
B-all diseases genes/prognosis/age
BCR-ABL(9:22) worst - adults
MLL t11q23 poor - baby
ETV6-RUNX1 (t12;21) - good - children
T-ALL prognosis, patient profile
Good (better young)
Males
Mediastinal mass
AML markers
CD34, HLADR, CD38 (immature)
CD117 (Ckit), MPO - myeloid markers
CD 34 =?
immature
CD117
myeloid
MPO
myeloid
TdT
lymphoid
Name AML disesases (6)
MLL 11q23 - poor RUNX1-RUNX1T1 (t8:21) good - young RBM15-MKL1 t(1:22) infant good PML-RARA t(15;17( APL) - good 2 t-aml - therapy
APL 2 things to know
treat with ATRA and risk for DIC
Aklyating agent –> MDS time
2-8 years; MDS –> AML
chr 5/7
Topo agent –> effect
1-2 yr; MLL 11q23
Three indicators of AML
FLT3-ITD
NPM1
CEBPA
MDS types
RCUD
RCMD
RAEB1
RAEB2
SLL/CLL markers
CD23
SMudge cell
Follicular lymphoma markers
BCL2 - prevents apoptosis
(CD19, 20, 10, BCL6)
t(14:18)
Mantle Cell lymphoma
t(11:14)
BCL1 - G1->S cell cycle
(CD5, 10, 20)
Burkitt’s lymphoma describe
t(8:14)
Starry sky appearence
MYC
Plasma cell - multiple myeloma signs
CRAB: high ca, renal insuff, anemia, bone lesion
M protein spike
CHL
RS cells
CD30 CD 15
Nodular sclerosis - broad collagen bands
Immunopathology types 1-4 basics
1 - allergies - IgE
2 - B cell - anitbody to self
3 - C complement
4 - Delayed/Tcell
SCID affects
T and B
Bruton’s X linked affects
B
affects X linked hyperIGM
class switch
CVID affects
no Ab
affects Digeorge
absent T (stroma cells) CATCH22- cardiac, ab face, thymic aplasia, celft palate, hypocal, chr 22
lacunar cells in
nodular sclerosis - CHL
CHL symptoms
fever, night sweats, painless lymphadenopathy, nephrotic syndrom/hypercalcemia
