HIGH YIELD Flashcards
ENHANCEMENT OF PHAGOCYTOSIS BY COATING OF FOREIGN PARTICLES WITH SERUM PROTEINS
OPSONIZATION
Jenner’s work with cowpox which provided immunity against smallpox demonstrates
CROSS IMMUNITY
The structure formed by the fusion of engulfed material and enzymatic granules within the phagocytic cell
phagolysosome
Two primary lymphoid organs
Bone marrow and thymus
Receptor on T cells responsible for rosetting with sheep RBC
CO2
Antigen binding sites in typical IGM
10
Antibody best at agglutination and complement fixation
IgM
Also known as T cell growth factor
IL-2
The classical complement pathway is activated by
Ag-Ab complexes
Role of properdin in the alternative pathway
Stabilization of C3/C5 convertase
Factor H acts by competing with __ for the same binding site
Factor B
A technologist who observes a red rash on her hands after removing her gloves
LAtex allergy
In the chain of infection, a contaminated work area would serve as
Source
The only biological waste that does not have to be discarded in a container with a biohazard symbol
urine
AN employee who receives an accidental needle stick should immediately
notify a supervisor
The first thing to do when acid is spilled on the skin is to
flush area with water
When. combining acid and water
Acid is added to water
To determine the chemical characteristics of sodium azide an employee would consult the
MSDS
Normal ratio of CD4 and CD8
2:1
Orchestrator or master regulator of the immune system
Helper T cell
Refer to as the leukocyte common antigen (LCA)
CD45
Referred to as the common acute lymphoblastic leukemia antigen (CALLA)
CD10
Immature dendritic cells within the epidermidis
Langerhans cells
MHC-1 restricted T cell that recognizes endogenous peptides
Cytotoxic T cell (CD8)
MHC-II restricted T cell that recognizes exogenous peptides
Helper T cell (CD4)
Change in the class of antibody being produced by the plasma cell
Isotype switching
Change in the class of antibody being produced by the plasma cell
Isotype switching
Efficiency of immunoglobulin G transfer across placenta
IgG1>IgG3>IgG4>IgG2
Immunoglobulin that can activate the Alternative pathway
IgA
Also know as millionaire antibody
IgG
Immature lymphocytes that recognize self-antigens in the central (generative) lymphoid organs are killed by apoptosis
Central tolerance/ Clonal deletion
Mature lymphocytes that recognize self-antigens in peripheral tissues become functionally inactive
Peripheral tolerance/ Clonal anergy
CREST syndrome
anti-centromere
X-linked immunodeficiency disorder characterized by the failure of B-cell precursors (pro-B cells and pre-B cells) to mature into B cells
Bruton’s Agammaglobulinemia
Risk of transmission of HIV is ___ with needle stick injury whereas the risk of hepatitis B is 30%
0.03%
Potential reservoir of HIV
Follicular dendritic cell
Most common cancer seen in px with AIDS
Kaposi’s sarcoma
Most sensitive SCREENING test for HIV
ELISA
Most specific CONFIRMATORY test for HIV
Western Blot
Most important initial test before considering a kidney transplant donor
Test for ABO
The only blood group system that affects clinical transplantation
ABO
HSV generally found in and around the ORAL cavity and in skin lesions that occur above the waist
HSV-1
Cross-reacting herpes
HSV-1 and HSV-2
HSV isolated primarily from the genital tract and skin lesions below the waist
HSV-2
Potential marker for stone disease
Cytokine that induces secretion of Ig and is a major factor in induction of the acute phase rnx; originally called interferon-B2 or B cell-stimulating factor-2
IL-6
Information about the patient such as name, gender, age, or birth date, referring or attending physician
Patient demographics
Anticoagulant for microlymphocytotoxicity testing
Acid citrated dextrose (ACD)
Lymphocyte population
TBNK
T-cells (60%-80%)
B-cells (10%-20%)
NK cells (<10%)
Complement-dependent cytotoxicity uses this type of microscope
Inverted phase contrast microscope
IN fluorescence polarization immunoassay (FPIA) the degree of fluorescence polarization is ____ proportional to concentration of analyte
INVERSELY
Hallmark rash of measles infection; bluish white spots with a red halo located on the buccal or labial mucosa
Koplik’s spot
Antigenic determinant
EPITOPE
Part of the antibody that binds to the antigen
PARATOPE
Immortal cell that produces antibodies
Plasma cell fused with myeloma cells
HYbridoma cells
Classic procedure for determining the HLA phenotype
Complement-Dependent Cytotoxicity test
Acute phase reactant that is useful as a marker of sepsis and is utilized for differentiating bacterial and non-bacterial meningitis
PROCALCITONIN
Gold standard in testing for contact dermatitis
PATCH TEST
Gold standards of EBV serology methods
IFA (Indirect Immunofluorescence Assay)
Gold standard for enumerating CD4 T cells
Immunophenotyping with flow cytometry
Gold standard for detecting hepatitis C virus and monitoring therapy
RT-PCR
