High Risk Pregnancy ✔️ Flashcards
describe 1st trimester testing
looks for pattern of biochemical markers associated with plasma protein A (PAPP-A)
maternal high risk factors
advanced maternal age - AMA abn maternal lab values vaginal bleeding insulin dependent diabetes mellitus HTN preeclampsia maternal systemic disease
describe 2nd trimester screening
performed with maternal serum quad screen lab value and targeted US exam
quad screen looks at following serum markers:
AFP
HCG
uE3
inhibin-A
define hydrops fetalis
condition in which excessive fluid accumulates within fetal body cavities
2 classifications of fetal hydrops
immune hydrops
non-immune hydrops
what is hydrops fetalis associated with
anasarca - massive edema ascites pericardial effusion pleural effusion placental edema polyhydramnios
describe immune hydrops
results from fetomaternal blood group incompatibility
blood group isoimmunization
Rh isoimmunization
indicated by presence of maternal serum antibody acting again fetal RBC antigen - sensitization
immune hydrops (IHF) Rh sensitization:
Rh- mom
Rh+ fetus
describe Rh sensitization
antibodies attack RBC’s
fetal hemolysis
hemolytic anemia
cardiac output > eventually leads to hydrops & erythroblastosis fetalis
what may be needed if Rh sensitization is present
blood transfusion in utero
O- blood transfusedd into umbilical vein
immune hydrops - perinatal death rate for Rh-sensitized pregnancies is _____% to _____% before intrauterine transfusions performed
25-35
**perinatal death rate has decreased significantly with modern treatment and care
an Rh ______ father and an Rh ______ mother my conceive an Rh positive baby
positive father
negative mother
immune hydrops sonographically
scalp edema pleural effusion pericardial effusion ascites polyhydramnios thickened placental > 5 cm
what does the indirect coomb’s test check for
maternal Rh antibodies
immune hydrops - potential of fetal anemia can be determined by
US surveillance - doppler of MCA
amniocentesis
cordocentesis
immune hydrops is rare today dut to ______
RhoGam
describe alloimmune thrombocytopenia
rare
mother may develop immune response to fetal platelets in manner similar to that of RBC’s
describe nonimmune hydrops
not a result of fetomaternal blood group incompatibility
disorders - cardio, chromo, hematologic, urinary, pulmonary, twin pregnancies, infectious diseases
to make a diagnosis of NIH (nonimmune hydrops), isoimmunization ruled out with _______ _______
antibody screening
nonimmune hydrops statistics
1 in 1500 to 1 in 3800 pregnancies
accounts for 90% of all hydrops cases
accounts for 3% of fetal mortality
nonimmune hydrops sonographically
scalp edema pleural effusion percardial effusion ascites cardiac abn's
bleeding in the 2nd and 3rd trimesters can be associated with what placental anomalies
placenta previa
placenta abruption
_______ _______ is the main cause for 3rd trimester bleeding
placenta previa
describe placenta previa
placenta covers internal cervical os and prohibits vaginal delivery of fetus
______ ______ is a rare condition in which umbilical cord is presenting part
vasa previa
_______ ________ is used to evaluate any structures in front of the cervical os to see if vascular
color doppler
________ ________ may cause vaginal bleeding during pregnancy
placental abruption
describe placental abruption
hypoechoic and 1-2 cm thick
thicker than 1-2 cm may be due to abruption or contraction
contraction should resolve within 20-30 minutes - use color doppler