HF drugs Flashcards
Which drug is a non-adrenergic peripheral vasoconstrictor which increases blood flow to the heart and brain?
Vasopressin
What are some adverse effects of Nesiritide?
Hypotension
GI upset
Vasopressin causes vasoconstriction in all vascular smooth muscle except ___________ & ________ in which, it causes vasodilation.
cerebral & coronary vessels
What are the adverse effects of vasopressin?
Nausea and vomiting (N/V)
abdominal cramps
Heart failure can be associated with hypervolemic hyponatremia. This can be treated with ____________________.
ADH antagonists.
What are 2 drugs that are ADH antagonists?
Tolvaptan
Conivaptan
“vaptan” drugs
Which of the following is a Pgp substrate and inhibitor?
A. Tolivaptan
B. Conivaptan
A
Which of the following is a CYP3A4 substrate and inhibitor?
A. Tolivaptan
B. Conivaptan
B
Which of the following is just a CYP3A4 substrate?
A. Tolivaptan
B. Conivaptan
A
True/False? Tolivaptan & Conivaptan have protein binding of 99%.
TRUE
What race of people are more "salt-sensitive"? A. caucasians B. African Americans (AA) C. Asians D. Native Americans
B. African Americans
Why can obstructive sleep apnea cause HTN?
How can you fix this?
if you’re not breathing, you’re CO2 increases and causes the heart to pump harder to compensate for the increased CO2 which can increase blood pressure
Tell pt to make sure they are using their CPAP because it can help decrease bp by 10 mmHg
Why can primary aldosteronism cause HTN?
it produces more aldosterone which increases Na+ and water retention (this increases volume –> increases bp)
Why can Cushing’s disease cause HTN?
cortisol enhances vasoconstriction which increases bp
List disorders that can cause secondary HTN.
Chronic Kidney Disease (CKD) Cushing's Disease Aortic Dissection Primary Aldosteronism Pheochyromocytoma ....
