Herpes Virus Summary Cards -- Tropisms

Question 1

What HHVs are in the alpha herpes group ?

what is the defining characteristic ?

Answer 1

Alpha Group:
HSV 1
HSV 2
VZV (HHV 3)

Charactersitic – blistering Rash

Question 2

What HHVs are in the beta herpes group?

what is the common characteristic

Answer 2

HHV 5 – CMV –(rarely causes roseola like rash)
HHV 6 – Roseola
HHV 7 – Roseola

Question 3

Gamma herpes group?

Answer 3

HHV 8 - kaposi’s sarcoma

HHV 4 - EBV

Question 4

which viruses cause mononucleosis?
Which are monospot positive?
which are monospot negative ?

Answer 4

monospot negative – HHV 6 and CMV

monospot positive – EBV

Question 5

which viruses are neurotropic?

Answer 5

HHV 1 - HSV 1
HHV 2 - HSV 2
HHV 3 - VZV

establish latency in DRG or cranial nerve ganglia
VZV can establish latency in the anterior horn

Question 6

Which viruses are lymphotropic

Answer 6

HHV4 (EBV), 5 (CMV), and 6 (HHV6)

HHV 4- EBV – binds to CR2 receptor
Can lead to Burkitt’s Lymphoma, Post Transplant Lymphoproliferative disease, hairy luekoplakia

CMV – persistent infection in lymphocytes
Latent infection in Hemopoetic Cells – patients become anemia, neutropenia, TTP

HHV 6 – infects B and T lymphocytes;

Question 7

Which virus is lymphotrophic and angiotrophic

Answer 7

HHV 8 - kaposi’s sarcoma