Herpes Simplex Virus Flashcards
What is HSV infection?
Lifelong latent infection when virus enters sensory neurons at infection site
What is this a presentation of?
Subclinical or sensory nerve tingling prodrome, then vesicles, shallow ulcers, heals 8-12 days later.
Primary HSV infection
What is this a presentation of?
Cold sore lesion at lip border.
Herpes labialis - HSV1
What is this a presentation of?
Fever, sore throat, followed by tender oropharyngeal vesicles.
Gingivostomatitis (HSV)
What is this a presentation of?
Painful vesicles on distal phalanx due to inoculation through a break in the skin.
Herpetic whitlow
What is this a presentation of?
Prodrome of fever, malaise, headache, nausea. Then encephalopathy, general/focal neurology, memory loss.
Herpes encephalitis (HSV1)
How is HSV infection diagnosed?
- Clinical
2. Viral PCR of CSF, swab or vesicle scrapping in CNS and immunocompromised
What is the treatment for HSV infection?
- Acyclovir - competitive inhibitor, DNA chain terminators
2. IV if encephalitis suspected