Herpes Simplex Virus Flashcards

1
Q

What is HSV infection?

A

Lifelong latent infection when virus enters sensory neurons at infection site

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2
Q

What is this a presentation of?

Subclinical or sensory nerve tingling prodrome, then vesicles, shallow ulcers, heals 8-12 days later.

A

Primary HSV infection

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3
Q

What is this a presentation of?

Cold sore lesion at lip border.

A

Herpes labialis - HSV1

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4
Q

What is this a presentation of?

Fever, sore throat, followed by tender oropharyngeal vesicles.

A

Gingivostomatitis (HSV)

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5
Q

What is this a presentation of?

Painful vesicles on distal phalanx due to inoculation through a break in the skin.

A

Herpetic whitlow

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6
Q

What is this a presentation of?

Prodrome of fever, malaise, headache, nausea. Then encephalopathy, general/focal neurology, memory loss.

A

Herpes encephalitis (HSV1)

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7
Q

How is HSV infection diagnosed?

A
  1. Clinical

2. Viral PCR of CSF, swab or vesicle scrapping in CNS and immunocompromised

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8
Q

What is the treatment for HSV infection?

A
  1. Acyclovir - competitive inhibitor, DNA chain terminators

2. IV if encephalitis suspected

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