Herpes Flashcards
What do HHV1/2 cause?
HSV
Oral/genital ulcers - painful
HSV-1: encephalitis
Neonatal herpes infection
What is the treatment of HHV1/2?
Oral acyclovir
What is HHV3?
VZV
Chickenpox/shingles
Ramsay hunt syndrome
Congenital varicella syndrome
How does HHV3 present?
dermatomal regions
vesicles/ulcers
What is the treatment of normal chickenpox?
Calamine lotion
Supportive
school exclusion - INFECTIOUS UNTIL LESIONS ARE DRY AND CRUSTED OVER (~5 days)
When does chickenpox require more serious treatment and with what
when immunocompromised or newborns w peripartum exposure
Rx: VZ Igs the IV aciclovir
Describe the rash in chicken pox
starts on head/trunk then spreads
macular->papular->vesicular
How is chickenpox spread
resp
What is HHV4? What does it cause?
EBV Causes: Glandular fever Burkitt's lymphoma Oral hair leukoplakia PTLD
What is the treatment of EBV ?
ganciclovir
How does glandular fever present?
Sore throat
Pyrexia
Lymphadenopathy
What happens when someone with glandular fever takes ampicillin/amoxicillin?
maculopapular, pruritic rash
How is glandular fever diagnosed?
FBC and monospot test - heterophil ab test
What is the management of glandular fever?
supportive - rest, simpel analgesia
avoid playing contact sports for 8 weeks after having it to reduce the risk of splenic rupture
What is HHV 5? How can it present?
CMV
Congenital CMV
CMV mononucleosis
CMV retinitis (HIV)
What is the features of congenital CMV?
growth retardation microcephaly sensorineural deafness encephalitis hepatosplenomegaly pinpoint petechial blueberry muffin lesions
What are the histological features of someone with CMV?
owls eye appearance on inclusion bodies
How does CMV retinas present? how does it present on fundoscopy?what is rx
blurred vision
retinal haemorrhages and necrosis
rx: IV ganciclovir
What is HHV 6?
roseola infantum
What is HHV 8?
Kaposi sarcoma
What is the rx of HHV 8?
Tocilizumab
ART
Cryotherapy
