Hereditary Cancer Syndrome - Genes

Question 1

p53

Answer 1

Li Fraumeni syndrome

Question 2

MEN1

Answer 2

Multiple endocrine neoplasia type 1 (MEN1)

Question 3

CDH1

Answer 3

Hereditary diffuse gastric cancer (HDGC)

Question 4

BRCA1/BRCA2

Answer 4

Hereditary breast and ovarian cancer syndrome (HBOC)

Question 5

FH

Answer 5

Hereditary leiomyotosis renal cell carcinoma (HLRCC)

Question 6

MLH1, MSH2, MSH6, PMS2, EPCAM

Answer 6

Lynch syndrome (HNPCC)

Question 7

RET

Answer 7

Multiple endocrine neoplasia type 2 (MEN2A and MEN2B); Familial medullary thyroid carcinoma (FMTC)

Question 8

PTEN

Answer 8

Cowden syndrome

Question 9

STK11/LKB1

Answer 9

Peutz-Jegher syndrome

Question 10

VHL

Answer 10

Von Hippel Lindau disease

Question 11

NF1

Answer 11

Neurofibromatosis type 1

Question 12

SDHD

Answer 12

PGL1 (familial paraganglioma type 1)

Question 13

SDHAF2

Answer 13

PGL2 (familial paraganglioma type 2)

Question 14

SDHC

Answer 14

PGL3 (familial paraganglioma type 3)

Question 15

SDHB

Answer 15

PGL4 (familial paraganglioma type 4)

Question 16

SDHA

Answer 16

PLG5 (familial paraganglioma type 5)

Question 17

TMEM127/MAX

Answer 17

Familial pheochromocytoma (Familial PC)

Question 18

FLCN

Answer 18

Birt Hogg Dube (BHD)

Question 19

Moderate penetrance breast cancer genes

Answer 19

CHEK2, PALB2, ATM

Question 20

Gene(s) to consider for: Adrenocortical carcinoma

Answer 20

p53 (LFS)

Question 21

Gene(s) to consider for: Carcinoid tumors

Answer 21

MEN1

Question 22

Gene(s) to consider for: Diffuse gastric cancer

Answer 22

CDH1

Question 23

Gene(s) to consider for: Fallopian tube and primary peritoneal cancer

Answer 23

BRCA1/BRCA2

Question 24

Gene(s) to consider for: Leiomyosarcoma

Answer 24

FH, Lynch genes

Question 25

Gene(s) to consider for: Medullary thyroid carcinoma (MTC)

Answer 25

RET (MEN2A/B, FMTC)

Question 26

Gene(s) to consider for: Paraganglioma/pheochromocytoma (PGL/PC)

Answer 26

RET (MEN2), VHL, NF1, SDHx (hereditary PGL/PC), TMEM127, MAX (familial PC)

Question 27

Gene(s) to consider for: Renal cell carcinoma - chromophobe

Answer 27

FLCN (Birt Hogg Dube)

Question 28

Gene(s) to consider for: Sebaceous Carcinomas

Answer 28

Lynch genes

Question 29

Gene(s) to consider for: Sex cord tumors with annular tubules

Answer 29

STK11 (PJS)

Question 30

BMPR1A/SMAD4

Answer 30

Juvenile Polyposis syndrome

Question 31

CDKN2A (p16)

Answer 31

Familial Atypical Multiple Mole Melanoma (FAMMM)

Question 32

MUTYH

Answer 32

MUTYH-Associated Polyposis (MAP)

Question 33

APC

Answer 33

Familial Adenomatous Polyposis (FAP), AFAP

Question 34

MET

Answer 34

Hereditary papillary renal carcinoma

Question 35

PRKAR1A

Answer 35

Carney Syndrome

Question 36

SMARCB1

Answer 36

Schwannomatosis

Question 37

Common APC AJ mutation

Answer 37

I1307K

Question 38

TSC1/2

Answer 38

Tuberous Sclerosis Complex

Question 39

Contiguous gene deletion of TSC1 and PKD1

Answer 39

TSC with ADPKD

Question 40

PTEN hamartoma syndromes

Answer 40

Cowden, Bannayan-Riley-Ruvacalba, Proteus and Proteus-like syndrome

Question 41

PTCH1

Answer 41

Nevoid-Basal Cell Carcinoma/Gorlin syndrome

Question 42

NF2

Answer 42

Neurofibromatosis Type 2

Question 43

PC, ERCC2, and POLH

Answer 43

Xeroderma Pigmentosum (XP)

Question 44

ATM

Answer 44

Ataxia Telangiectasia

Question 45

RB1

Answer 45

Retinoblastoma

Question 46

FWT1/FWT2

Answer 46

Wilms tumor

Question 47

BLM

Answer 47

Bloom syndrome

Question 48

NBN

Answer 48

Nijmegen breakage syndrome

Question 49

SPRED1

Answer 49

Legius syndrome