hepc- other, thyroid

Question 1

Porphyria Cutanea Tarda (PCT)

• Caused by a deficiency in

Answer 1

uropoprhyrinogen decarboxylase (UROD);

Question 2

mechanisms transmission

Answer 2

inherited,sporadic or associated with Hepatitis C

Question 3

___ form may occur in association with HCV; in one study___% of patients with PCT
had HCV-antibodies

Answer 3

• Sporadic

82

Question 4

alcohol, estrogens, and polyhalogenated hydrocarbons

Answer 4

environmental triggers hep c

Question 5

facial hypertrichosis, hyper/hypopigmentation, skin fragility and sclerodermoid changes.

Answer 5

hcv

Question 6

The pathogenesis of HCV related PCT might be related to

Answer 6

decompartmentalization of iron stores resulting in formation of free iron radicals and oxidation of UROD

Question 7

phlebotomy to decrease iron load, interferon based regimens and
avoidance of triggering factors

Answer 7

Treatment hcv

Question 8

Lichen Planus

• Incidence of HCV in patients with lichen planus varies from

Answer 8

0.1% to 35%, depending on region

Question 9

• Treatment with interferon impact skin lesions

Answer 9

both worsening and improvement of the

Question 10

Polyarteritis Nodosa___% of patients were HCV+

Answer 10

12-31

Question 11

also associated with Hepatitis B

Answer 11

Polyarteritis nodosa

Question 12

Pruritus in chronic HCV infection

pathogenesis may be related to but not always a direct correlation

Answer 12

elevated bile salt levels that occur in the setting of liver failure

Question 13

cholestyramine, ursodeoxycholic acid, rifampin, naltrexone,

thalidomide, and UVA, UVB and interferon alpha

Answer 13

• Treatment regimens hcv pruritus

Question 14

• Erythema nodosum
• Erythema multiforme
• Unilateral nevoid telangiectasia
• Pyoderma gangrenosum
• Vitiligo
• Psoriasis

Answer 14

Uncommon Associations hep c

Question 15

Behçet’s syndrome
• Mooren corneal ulcers
• Granuloma annulare
• Disseminated superficial actinic porokeratosis

Answer 15

Uncommon Associations hep c

Question 16

alopecia, lichenoid eruption,
eczema, malar erythema, and local
cutaneous necrosis

Answer 16

most frequently reported

cutaneous findings with interferon

Question 17

combination of interferon α and ribavirin. T

Answer 17

Currently the best management of Hepatitis C is the

Question 18

cutaneous reactions were
more common in the group on combination interferon/ribavirin therapy therapy
T/F

Answer 18

T

Question 19

Thyroglossal Duct Cyst
Malignant degeneration to
papillary adenocarcinoma COMMON?

Answer 19

F. rare

Question 20

Metastases to the skin from a thyroid malignancy is rare but Most reported cases occur with

Answer 20

papillary adenocarcinoma

Question 21

Sipple syndrome, Sipple syndrome, autosomal dominant

MEN 2b/III

Answer 21

medullary thyroid carcinoma, pheochromocytoma, and parathyroid
hyperplasia/adenomas.

medullary thyroid carcinoma,
pheochromocytoma, marfanoid features, and gastrointestinal ganglioneuromatosis.

Question 22

Skin findings in Sipple syndrome are rare but may include

Answer 22

lichen or macular amyloidosis

Question 23

Sipple syndrome gene defect

Answer 23

RET proto-oncogene, which encodes a tyrosine receptor kinase.

Question 24

most common skin finding is mucosal neuromas.

Answer 24

MEN 2b/III

Question 25

Other associated cutaneous findings | include perioral and acral hypopigmentation, café-au-lait macules, and cirumoral lentigines

Answer 25

MEN 2b/III

Question 26

defect in the PTEN tumor supressor gene, which encodes a protein phosphatase.

Answer 26

Cowden’s syndrome (multiple hamartoma syndrome) autosomal dominant due to a

Question 27

trichilemmomas, acral keratoses, oral papillomas, acanthosis nigricans, lipomas, facial dysmorphism and bony abnormalities and macrocephaly

Answer 27

Cowden’s syndrome

Question 28

increased risk of thyroid adenomas, thyroid goiter, thyroglossal duct cyst, and are at andeveloping the follicular type of thyroid carcinoma. fibrocystic breast disease, breast cancer and Lhermite Duclos disease (dysplastic gangliocytoma of cerebellum)

Answer 28

Cowden’s syndrome

Question 29

• Thyroid dermopathy May progress to resemble

Answer 29

elephantiasis verrucosa nostra.

Question 30

Can occur in the euthyroid, | hypothyroid, or hyperthyroid state.

Answer 30

Thyroid dermopathy

Question 31

Thyroid dermopathy pathogenesis

Answer 31

increase in hyaluronic | acid in dermis.

Question 32

vitiligo, anetoderma, dermatitis herpetiformis, mid-dermal elastolysis, herpes gestationis, pemphigus vulgaris, and Sweet’s syndrome

Answer 32

• Cutaneous conditions associated with Grave’s disease

Question 33

thick, pale protuberant lips, delayed dentition, an enlarged tongue, wide set eyes, a broad flat nose, dwarfism, cutis marmorata, cardiac defects, gastrointestinal and skeletal defects

Answer 33

Congenital hypothyroidism

Question 34

binding of excess organic iodide in the thyroid gland with resultant inhibition of thyroid hormone synthesis. occur in the setting of patients with

Answer 34

Wolff-Chaikoff effect WCE

Question 35

``` erythema nodosum (or other inflammatory dermatoses) being treated with potassium iodide ```

Answer 35

Wolff-Chaikoff effect WCE

Question 36

• Thyroid dermopathy May progress to resemble

Answer 36

elephantiasis verrucosa nostra.

Question 37

Can occur in the euthyroid, | hypothyroid, or hyperthyroid state.

Answer 37

Thyroid dermopathy

Question 38

Thyroid dermopathy pathogenesis

Answer 38

increase in hyaluronic | acid in dermis.

Question 39

vitiligo, anetoderma, dermatitis herpetiformis, mid-dermal elastolysis, herpes gestationis, pemphigus vulgaris, and Sweet’s syndrome

Answer 39

• Cutaneous conditions associated with Grave’s disease

Question 40

thick, pale protuberant lips, delayed dentition, an enlarged tongue, wide set eyes, a broad flat nose, dwarfism, cutis marmorata, cardiac defects, gastrointestinal and skeletal defects

Answer 40

Congenital hypothyroidism

Question 41

binding of excess organic iodide in the thyroid gland with resultant inhibition of thyroid hormone synthesis. occur in the setting of patients with

Answer 41

Wolff-Chaikoff effect WCE

Question 42

``` erythema nodosum (or other inflammatory dermatoses) being treated with potassium iodide ```

Answer 42

Wolff-Chaikoff effect WCE