Hepatology Flashcards
1
Q
Primary Biliary Cholangitis
- Definition
- Presentation
- Investigations
- Mx
- Complications
A
Destruction of intrahepatic biliary duct due to chronic inflammation -> cirrhosis
90% of patients are female
Typical presentation: itching middle aged women.
IX: Cholestatic liver panel, AMA positive
MX: Pruritus:cholestyramine Fat-soluble vitamin supplementation Ursodeoxycholic acid Liver transplantation
Comp: Cirrhosis, HCC
2
Q
Primary Sclerosing Cholangitis
- Definition
- Presentation
- Investigations
- Mx
- Complications
A
Inflammation and fibrosis of intra and extra hepatic ducts.
75% are men.
A/W: UC, CD, AIH, HIV
Clinical features
Cholestasis: jaundice and pruritus
RUQ pain
Fatigue
IX: Cholestatic LFT, pANCA +ve, ERCP/MRCP
MX: Symptomatic tx, Liver transplant
Comp: Cholangiocarcinoma, CRC
3
Q
What is the gold standard for diagnosing PSC?
A
MRCP/ERCP
