Hepatobiliary

Question 1

Diseases seen w/ Microvesicular Steatosis?

Answer 1

• Acute fatty liver of pregnancy

- Valproic acid toxicity

Question 2

Diseases seen w/ Macrovesicular Steatosis?

Answer 2

• Obesity
• Diabetes
• Hepatitis C

Question 3

Diseases seen w/ Mixed Micro/Macrovesicular Steatosis?

Answer 3

Alcoholic fatty liver disease

Question 4

Describe the histology seen in Acute Steatohepatitis (alcoholic)

Answer 4

Liver cells with ballooned cytoplasm, Mallory

material (condensed intermediate filaments), surrounded by inflammatory cells

Question 5

Describe the histology seen in Acute large bile duct obstruction (early, first couple of days)

Answer 5

Centrolobular canalicular cholestasis and mild reactive changes in the hepatocytes
(feathery degeneration, intracellular cholestasis, canalicular cholestasis)

Question 6

What is Lipofuscin?

Answer 6

Lipofuscin forms as fine, light brown, PAS‐positive and acid‐fast granules. It is a breakdown product of lysosomal material, reflecting cell activity, and is referred to as ‘wear and tear’ pigment. More prominent in the pericentral hepatocytes (zone
3), also tends not to be in periportal hepatocytes.

Question 7

Where does copper deposition occur in Wilson Disease?

Answer 7

Zone 1 hepatocytes

Question 8

What is Mallory Weiss Syndrome?

Answer 8

Esophageal Lacerations that are induced by forceful, prolonged vomiting of chronic alcoholism and can extend to submucosal veins that bleed profusely.