Hepatobiliary Flashcards

1
Q

Laparoscopic CBD exploration

A
  1. Incise cystic duct, place wire, use baloon dilator to dilate duct
  2. Hook cholecoscope up to saline, advance into duct
  3. Visualize stones, extract with wire basket, drive scope into duo if necessary
  4. Withdraw scope, shoot completion cholangiogram
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Open CBD Exploration

A
  1. 2 cm Longitudinal incision in CBD with a 15 blade and potts scissors
  2. Place stay sutures to open up the duct
  3. Pass #4 fogarty catheter,***
  4. Choledochoscope, make sure hooked up to saline, visualize stones, extract with wire basket
  5. Place t-tube and shoot cholangiogram, secure t-tube with 4-0 PDS interrupted sutures
  6. T-tube can be capped if no leak on pre-discharge cholangiogram; it can come out in 2 weeks after that
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Distal pancreatectomy & splenectomy

A
  1. Enter lesser sac by separating greater omentum from transverse colon, lifting posterior gastric wall away from pancreas & divide short gastric vessels
  2. Mobilize splenic flexure to expose inferior pancreas. Mobilize pancreas away from splenic vein and artery using energy device & clips. Create tunnel behind neck of pancreas.
  3. Use stapler to divide pancreas at neck, 2 cm to right of tumor, send for frozen section
  4. Isolate, then transect splenic artery then vein w vascular stapler, taking LN’s w specimen
  5. Mobilize pancreas off retroperitoneum, taking peripancreatic fat
  6. Mobilize spleen off lateral attachments
  7. Leave a drain
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Pancreatic debridement

A
  1. Midline laparotomy
  2. Enter lesser sac through omentum or transverse colon
  3. Manually debride necrotic pancreatic tissue
  4. Place large sump drains
  5. Place g-tube and feeding J-tube
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Pancreatic pseudocyst drainage

A
  1. Midline laparotomy
  2. Incise anterior stomach
  3. Aspirate contents with needle
    incise 3-4cm posterior stomach and some cyst wall, elipse this out, send cyst wall to path for frozen to be sure not cystic neoplasm with epithelial lining
  4. Running 3-0 pds suture for hemostasis to create the cyst-gastrostomy
  5. Close anterior gastrostomy in 2 layers
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Splenectomy

A

Vaccinate for encapsultated organisms: pneumococcus, meningococcus, h-flu

  1. 45 degree right lateral decubutus
  2. Hassan supraumbilical; Look for accessory spleen tissue in splenic hilum, omentum
  3. Mobilize splenic flexure of colon
  4. Enter lesser sac by dividing omentum, divide short gastrics
  5. Take hilum with vascular stapler, taking care not to involve the tail of the pancreas
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Cholecystectomy

A

Hassan
1. Incise peritoneum overlying gallbladder at the neck, expose the critical view of safety
2. perform cholangiogram if indicated
3. clip and divide duct and the artery
take gallbladder off the cystic plate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Roux en Y HJ

A
  1. Right subcostal incision
  2. Portal exposure via mobilization of duodenum, omentum, hepatic flexure away from porta
  3. Anterior only dissection of hepatic duct & lowering of hilar plate to expose confluence
  4. Fashion tension free Roux limb to RUQ - start at LOT count 20 cm distal, divide bowel with stapler, bring roux limb up to the bile duct through defect in transverse mesocolon to R of middle colic vessels
  5. Complete broad biliary enteric anastomosis
  6. Perform stapled side to side JJ anastomosis 50 cm distal; close JJ & Peter sons defect
  7. Leave a drain
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Whipple

A
  1. Dx laparoscopy
  2. Enter lesser sac, expose infra pancreatic SMV, & develop plane behind neck of pancreas and encircle w umbilical tape
  3. Mobilize hepatic flexure and perform extended Kocher maneuver
  4. Cholecystectomy, portal dissection, transection of common bile duct, identification & ligation of GDA
  5. Transect stomach, dissect LOT, transect jejunum 20 cm distal to LOT, rotating duodenum under mesenteric vessels
  6. Transect pancreas @ neck & send distal margin for frozen section & complete RP dissection by removing specimen from SMV-PV & SMA margin
  7. Pancreatic-jejunostomy, hepatico-jejunostomy, & gastrojejunostomy & leave drains
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Liver segments & partial hepatectomy steps

A

Partial hepatectomy general steps:
1. Mobilization
2. cholecystectomy & cannulation of cystic duct
3. isolation & control of vascular structures
4. Ligation of hepatic artery, PV, then hepatic vein
5. Division hepatic parenchyma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Functional liver remnant required in cirrhotic vs Childs A cirrhotic

A

No cirrhosis → 25%
Childs A → 30-40%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Work up for bile duct injury

A

Begin w U/S & CT
HIDA has limited role unless unable to tell from U/S & CT
MRCP with Eovist is good next step for anatomy
Next is cholangiography w ERCP vs PTC with transhepatic biliary drain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Management of BD injuries

A - cystic duct or accessory duct leaks; EHBD in continuity
B - ligation & division of anomalous R sided segmental hepatic duct; EHBD partial continuity
C - leakage from R sided anomalous duct; difficult to see with ERCP!; EHBD partial continuity
D - lateral injury to biliary tree; EHBD in continuity

Type E are “major,” EHBD not in continuity

A

Type A-D are “minor”
A - cystic duct or accessory duct leaks; EHBD in continuity → ERCP sphincterotomy & stent placement
B - ligation & division of anomalous R sided segmental hepatic duct; EHBD partial continuity → Roux en Y HJ if symptomatic
C - leakage from R sided anomalous duct; difficult to see with ERCP!; EHBD partial continuity → Percutaneous transhepatic biliary drainage followed by Roux en Y HJ
D - lateral injury to biliary tree; EHBD in continuity → ERCP sphincterotomy & stent placement; HJ if refractory stricture develops

Type E are “major,” EHBD not in continuity → Percutaneous transhepatic biliary drainage followed by Roux en Y HJ

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Types of choledochal cysts and management

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Gallbladder adenocarcinoma management

A

Primary tumor
T1a: invades lamina propria
T1b: invades muscle
Surgical treatment

If muscle is not involved (T1a) – cholecystectomy sufficient
If T1a, but at cystic duct margin → resect cystic duct to obtain negative margins

If in muscle but not beyond (T1b)& resectable (need CT chest/abd/pelvis)
1. Staging laparoscopy - examine port sites - convert to open if resectable
2. Portal lymph node dissection - skeletonize common hepatic artery beginning w cystic duct node, then PV, then CBD but dont devascularize…
3. Wedge resection of segments IVb and V for 2 cm negative margin

Chemotherapy: Capecitabine or Gemcitabine/Cisplatin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Management of echinococcal cysts

A

Depending on stage and size of the cyst, options include, Albendazole vs Albendazole w treatment (PAIR, large bore percutaneous treatment, or surgery)

PAIR = puncuture, aspiration, injection w ETOH/scolicidal agent, reaspiration

17
Q

Hepatic hemangioma appearance & management

A

CT: Late contrast puddling is pathognomonic
PERIPHERAL enhancement on ARTERIAL phase
CENTRIPETAL filling on PORTAL VENOUS phase
Retention of contrast on washout or delayed phase
Tx: angioembolization for bleeding; enucleation if symptomatic

18
Q

LI-RADS factors & score

A
  1. Arterial phase hyperenhancement
  2. Enhancing capsule
  3. Non-peripheral washout
  4. Threshold growth
19
Q

LI-RADS score and general management

A

High LIRADS Scoring (4 to 5 = Heterogenous; Early arterial enhancement and washout of contrast on delayed phase) & appropriate hx is diagnostic for HCC

DONT FORGET CEA, AFP, CA199, & CHEST CT FOR STAGING

20
Q

Hepatic adenoma work up & management

A

Hx of OCP &/or steroids

RISK OF BLEEDING & MALIGNANT TRANSFORMATION (5%)

Appears well-marginated, isointense on NC CT; HYPERINTENSE on ARTERIAL phase; rapid washout; +/- heterogenous due to hemorrhage
– No Eovist (Gd) [MRI] or sulfur colloid [NM scan] retention (no Kupffer cells) UNLIKE FNH

Management
Discontinue estrogen agents & maintain ideal body weight

Bleeding → embolize, repeat MRI in 6 months
Men → Resect
Women → Resect if symptomatic or if lesion is >5 cm or if pregnant?

21
Q

FNH management

A

No risk of bleeding or malignant transformation
CT: homogenous mass with CENTRAL scar; HYPERINTENSE on ARTERIAL phase
Central Scar: hypoattenuating on arterial phase; hyperattenuating on delay
Eovist (Gd) and sulfur colloid uptake (+ Kupffer cells)

22
Q

HCC Work Up

A

H&P focus on GI cancer (colonoscopies, rectal bleeding, etc) & liver disease (hepatitis, ETOH, IVDU, smoking, NASH etc) vs infection

Labs for liver fx
Child-Turcotte-Pugh score
Bilirubin, Albumin, PT, encephalopathy, ascites

MELD
Bilirubin, INR, creatinine

Need triple phase CT scan & CHEST CT

23
Q

HCC management for Child-Pugh A vs B/C (hint - know Milan criteria)

A

Resection with 1 cm margins is appropriate if good hepatic reserve (Child-Pugh A) but all patients should be offered transplant bc high risk of recurrence

Liver Transplant: Milan Criteria (gold standard for patients with Child-Pugh B/C cirrhosis & limited hepatic reserve)
–Single lesion < 5 cm
–Up to 3 lesions, each < 3 cm
–No extra-hepatic metastatic disease or major vessel involvement

Local therapies if not candidate for surgery
–TARE: transarterial radioembolization
–TACE: transcatheter arterial chemoembolization
–HAIC: hepatic arterial infusional chemotherapy
–SBRT: stereotactic body radiation therapy
–RFA: radiofrequency ablation

24
Q

Pancreatic cyst work up - dont forget to ask about these in H&P

A

Things to ask in history
1. ETOH, smoking, diabetes, pancreatitis
2. Hypoglycemia (Insulinoma)
3. Refractory ulcers (Gastrinoma)
4. Diabetes, dermatitis, DVT (Glucagonoma)
5. Cholecystitis, steatorrhea (Somatostatinoma)
6. Watery diarrhea (VIPoma)

Imaging & labs
1. DONT FORGET CA-19-9, CEA
2. MRCP & usually EUS with FNA to assess cyst cytology, amylase, CEA, mucin, DNA analysis (KRAS)

25
Q

Pancreatic cyst features - know features, cytology, amylase levels, CEA & Mucin for 1. pseudocyst, 2. SCN/SCA, 3. MCN, 4. SPN, 5.IPMN

A

Resect all SPN, MCN, IPMN-MD, & IPMN-BD w borderline features

26
Q

IPMN-BD high risk features

A

High risk features → Consider surgery without further evaluation
MRCP
–Main duct ≥10 cm
–Enhancing mural nodule ≥5 mm
–Obstructive jaundice

27
Q

IPMN-BD worrisome features

A

Pancreatitis
Cyst ≥3 cm
Thickened/enhancing cyst wall
Main duct 5-9 mm
Non-enhancing mural nodule < 5 mm
Abrupt change in the caliber of pancreatic duct w distal atrophy, elevated CA-19-9

Need EUS/FNA

28
Q

Management of IPMN-BD without high risk or worrisome features

A

<1 cm → CT/MRI in 2-3 years
1-2 cm → CT/MRI yearly for 2 years
2-3 cm → EUS in 3-6 m, consider surgery in young/healthy
>3 cm → EUS in 3-6 m, strongly consider surgery in young/healthy

29
Q

Laparoscopic distal pancreatectomy - Spleen preserving

A

Hasson access, 4x 5 mm ports triangulated to LUQ, examine for mets

Mobilize stomach - enter lesser sac by separating greater omentum from transverse colon, lifting posterior gastric wall away from pancreas

Examine pancreas from duodenum to splenic hilum to verify location of lesion & relationship to main duct & vessels - identify splenic artery along superior border of pancreas

Mobilize splenic flexure to expose inferior pancreas. Mobilize pancreas away from splenic vein and artery using energy device & clips

Use stapler to divide pancreas at neck, 2 cm to right of tumor, send for frozen section (if HGD, need negative margins! LGD does not)

Mobilize pancreas off retroperitoneum, taking peripancreatic fat

Leave a drain

30
Q

PNET work up

A

H&P - cancer risk factors (smoking, personal/family history malignancy, personal/family hx of endocrine/MEN syndrome) & endocrine symptoms -
Hypoglycemia (Insulinoma)
Refractory ulcers (Gastrinoma)
Dermatitis, DVT, diabetes (Glucagonoma)
Cholecystitis, steatorrhea (Somatostatinoma)
Watery diarrhea (VIPoma)

Labs
Fasting C peptide, insulin, glucose
Fasting gastrin
Fasting glucagon
Fasting somatostatin
Fasting VIP

Ask for EUS & bx to confirm dx, determine grade/differentiation, Ki67

Triple phase CT is usually sufficient but get Dototate-PET to r/o mets/distant disease

31
Q

Management of nonfunctional PNET

A

Elevated Ki67

Most are malignant
<2 cm & no symptoms → observe w repeat CT in 6 months, then yearly MRI if stable

If malignant features present, formal resection necessary (includes spleen in tail)

32
Q

Insulinoma diagnosis & management

A

Most are single & benign (90%)
Location → Evenly distributed

Sxs: “Whipple Triad:” Fasting hypoglycemia, neuroglycopenic symptoms, relief of symptoms after glucose

Dx:
Fasting glucose (Symptoms w glucose < 55 mg/dL)
Fasting Insulin > 18 pmol/L
Fasting C-peptide ≥ 0.6 ng/mL

Localization (NOT somatostatin scintigraphy; only PNET that can’t be tx w octreotide):
1. Triphasic CT/MRI___2. EUS___3. selective intra-arterial calcium injection w hepatic venous sampling for insulin

Tx: Enucleation usually ok unless close to duct then better off w formal resection

33
Q

Gastrinoma diagnosis & management

A

Mostly malignant
Sporadic forms (80%) - usually solitary tumor within duodenum, most are cured w/ surgery
Familial forms (20%) - associated with MEN I, more aggressive

Location → Triangle (cystic duct/CBD, D2/D3, pancreas neck/body); usually arise in D1, only 25% found in pancreas

Sxs: Triad of abdominal pain, diarrhea, weight loss in setting of PUD

Dx:
Elevated fasting gastrin (>1000 pg/mL) in setting of low pH is dx
If < 1000 pg/mL → Secretin stimulation test (increased gastrin more than 120 pg/mL above basal level at 10 minutes)

Localization:
1. Triphasic CT/MRI___2. SRS___3. EUS ___4. selective arteriography___5. OR

Tx:
Need chole
Duodenal mucosa or noninvasive & < 5 cm in head of pancreas → Enucleation w LN dissection
> 5 cm or invasive in head of pancreas → Whipple

34
Q

Glucagonoma diagnosis & management

A

Mostly malignant

Location → Tail of pancreas

Sxs: Dermatitis (necrolytic migratory erythema), Diabetes, Depression, DVT (F X-like antigen)

Dx: Glucose intolerance & fasting glucagon 1,000-5,000 pg/mL

Localization:
1. Triphasic CT/MRI___2. SRS___3. EUS ___4. selective arteriography

Tx: Resection with regional lymphadenectomy & cholecystectomy

35
Q

Somatostatinoma diagnosis & management

A

Mostly malignant
Location → Most frequent PNET at head of pancreas

Sxs: Cholecystitis, DM, malabsorption, steatorrhea

Localization:
1. Triphasic CT/MRI___2. SRS___3. EUS ___4. selective arteriography

Tx: Resection with regional lymphadenectomy & cholecystectomy

36
Q

VIPoma diagnosis & management

A

Mostly malignant, usually single
Location → Body or tail of pancreas (can also be extra-pancreatic)

Sxs: WDHA syndrome

Dx: Elevated fasting VIP & diarrhea

Localization:
1. Triphasic CT/MRI___2. SRS___3. EUS ___4. selective arteriography

Tx: Resection with regional lymphadenectomy & cholecystectomy