Hepatitis virus table 18-3

Question 1

Hepatitis A

Answer 1

• ssRNA
• Hepatovirus; related to picornavirus
• Fecal-oral transmission (contaminated food or water)
• incubation pd= 2-6 wks
• NEVER causes chronic liver dz!!
• Dx: detection of serum IgM Abs

Question 2

Hep B

Answer 2

• Partially dsDNA
• Hepadenavirus
• Parenteral, sexual contact, perinatal
• incubation pd: 2-26 wks (mean 8 wks)
• 5-10% have/progress to chronic liver disease
• Dx: detection of HBs Ag or Ab to HBc Ag; PCR for HBV DNA

Question 3

Hep C

Answer 3

• ssRNA
• Flaviviridae
• Parenteral; intranasal cocaine use is risk factor
• incubation: 4-26 wks (mean=9wks)
• > 80%=chronic liver dz
• Dx: 3rd generation ELISA for Ab detection; PCR for HCV RNA

Question 4

Hep D

Answer 4

• circular defective ssRNA
• Subviral particle in Deltaviridae family
• Parenteral transmission
• incubation: 2-26 wks (mean=8wks)
• 10%=chronic liver dz for confection and 90-100% for superinfection
• Dx: Detection of IgM and IgG Abs; HDV RNA serum; HDAg in liver

Question 5

Hep E

Answer 5

• ssRNA
• Hepevirus
• Fecal oral transmission
• 4-5 wk incubation
• chronic liver dz In immunocompromised only
• Dx: Detection of serum IgM and IgG Abs; PCR for HEV RNA