Hepatitis/Liver Disease

Question 1

Sovaldi

Answer 1

Sofosbuvir

Question 2

Harvoni

Answer 2

Sofosbuvir + ledipasvir

Question 3

Epclusa

Answer 3

Sofosbuvir + Velpatasvir

Question 4

Vosevi

Answer 4

Sofosbuvir + Velpatasvir + Voxilaprevir

Question 5

Mavyret

Answer 5

Glecaprevir + Pibrentasvir

Question 6

Viekira Pak

Answer 6

Paritaprevir/ritonavir/Ombitasvir + Dasabuvir

Question 7

Suffix for NS3/4A PIs

Answer 7

-previr

Question 8

Suffix for NS5A replication complex inhibitors

Answer 8

-asvir

Question 9

Suffix for NS5B polymerase inhibitors

Answer 9

-buvir

Question 10

Zepatier

Answer 10

Elbasvir/grazoprevir

Question 11

HCV treatment algorithm

Answer 11

2-3 DAAs +/- ribavirin x 12 weeks

Mavyret x 8 weeks

Question 12

Pan-genotypic DAAs

Answer 12

Epclusa, Mavyret

Question 13

DAAs that have DDI with acid suppressant therapy

Answer 13

Harvoni, Epclusa, Vosevi

Question 14

DAAs that treat HCV/HIV co-infection

Answer 14

Harvoni, Epclusa, Mavyret

Question 15

DAAs salvage therapy

Answer 15

Vosevi, Mavyret

Question 16

Ribavirin SE

Answer 16

Teratogenic, hemolytic anemia

Question 17

Drugs used to treat HepB

Answer 17

(NRTIs) TDF, TAF, lamivudine, telbivudine, entecavir, adefovir

Question 18

Hepatotoxic drugs (d/c if LFTs > 3x ULN)

Answer 18

APAP, isoniazid, nevirapine, NRTIs, tipranavir, valproic acid

Question 19

Drugs for relapse prevention for alcoholic liver disease

Answer 19

Naltrexone (ReVia, Vivitrol)
Acomprasate (Campral)
Disulfiram (Antabuse)