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Spring Pharm Exam 1 > Hepatitis Drugs > Flashcards

Hepatitis Drugs Flashcards

1
Q

What is SVR?

A

Sustained virologic response = cure

Undetectable RNA after 12 weeks of tx

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2
Q

Ribavirin MOA

A

Guanosine analog

Inhibits viral RNA dependent polymerase via competitive inhibition

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3
Q

AE of ribavirin

A

Not that efficacious
Hemolytic anemia
Teratogenic

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4
Q

Interferon MOA

A

Jolt to immune system that has antiviral, immunomodualtory, and antiproliferative actions

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5
Q

AE of interferons

A

BAD flu Iike sx

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6
Q

Simeprevir

A

HCV protease inhibitor

AE: rash, photosensitivity, drug intxns CYP3a4

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7
Q

Sofosbuvir

A

HCV polymerase inhibitor
Pangenotypic
Contra: severe renal

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8
Q

Ledipasvir

A

NS5A protein inhibitor, targets RNA replication assembly
HCV genotype 1
Only available in Harvoni
Good for HCV/HIV co-infection

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9
Q

Harvoni

A

Sofosbuvir

Ledipasvir

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10
Q

BBW for all direct acting HCV drugs

A

Can lead to HBV reactivation in a co-infection

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Spring Pharm Exam 1 (6 decks)

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