Hepatitis Drugs

Question 1

Peginterferon alfa

Answer 1

Agent for Hep B and Hep C (chronic)
More finite treatment, no resistance, more durable response
MOA: Inhibits viral function, enhances macs, augments cytotoxic T-cells
Side effects: flu-like illness, increase hepatic enzymes, neurotoxicity, myelosuppression, and profound fatigue
Contraindicated in hepatic decomposition and caution with psychiatric disease
May increase theophylline and methadone
Shouldn’t use with didanosine or zidovudine

Question 2

Adefovir

Answer 2

Agent for Hep B
Nucleoside/Nucleotide Analogs
Interfere with viral replication (DNA polymerase)

Question 3

Entecavir

Answer 3

Agent for Hep B

Question 4

Lamivudine (3TC)

Answer 4

Agent for Hep B

Question 5

Telbivudine

Answer 5

Agent for Hep B

Question 6

Tenofovir

Answer 6

Agent for Hep B

Question 7

Ribavirin

Answer 7

Agent for Hep C

Question 8

Simeprevir (Olysio)

Answer 8

Agent for Hep C

Question 9

Sofosbuvir (Sovaldi)

Answer 9

Agent for Hep C

Question 10

Boceprevir (Incivek)

Answer 10

Agent for Hep C

Protease Inhibitor

Question 11

Telaprevir (Victrelis)

Answer 11

Agent for Hep C

Protease Inhibitor

Question 12

HAV summary

Answer 12

RNA virus
Fecal-Oral transmission
Supportive care only

Question 13

HBV summary

Answer 13

dsDNA virus
Sexual, parenteral, and perinatal
HBsAg = infectious
HBsAb = recovery or vaccinated
HBcAb = previous or current infection (IgM = recent)
HBeAg = viral replication
HBeAb = viral clearance
Virion = Dane Particle
Not curable

Question 14

HCV summary

Answer 14

RNA virus
Sexual, parenteral, and perinatal (**IV drug abuse)
Most common blood borne pathogen

Question 15

Contraindications to treat HCV

Answer 15

Decompensated liver disease

Uncontrolled psychiatric disorder

Question 16

Favorable treatment response for HCV

Answer 16

HCV genotype 2 or 3
Absence of cirrhosis
Low pretreatment HCV RNA level