Hepatitis Drugs Flashcards
What is sustained virology response
undetectable viral load for 12 weeks after finishing or 24 weeks after finishing with cirrhosis
Protease inhibitors end with
previr
NS5A inhibitors end with
asvir
Polymerase inhibitors end with
buvir
What are antivirals for treatment naive HCV? what about treatment experienced?
Naive: harmony, epclusa, mavyret (without protease i), zepatier
Experienced: vosevi, mavyret (with protease)
What does the Child Pugh score give indication about? what are the 3 classes?
severe liver disease
Class A 5-6 points
Class b 7-9 points
Class C 10-15 points
Do not use protease inhibitors in people with child Pugh score:
B or C (decompensated cirrhosis)
Which two (generic name) antiviral medications have sofosbuvir?
Harvoni and Epclusa
What genotypes does Harvoni treat
1, 4, 5, 6
Harvoni should be used for ___ weeks and can be used in _____
8 weeks
decompensated cirrhosis
What genotypes does Epclusa treat?
all genotypes
Epclusa should be used for ___ weeks and can be used in ______
12 weeks
decompensated cirrhosis
What antivirals are in Harvoni
ledipasvir and sofosbuvir
What antivirals are in epclusa
Velpatasir and sofosbuvir
What antivirals are in mavyret
flecaprevir and pibrentasvir