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BPT Gastroenterology > Hepatitis B > Flashcards

Hepatitis B Flashcards

1
Q

What is the most common cause of transmission of HBV?

A

vertical/perinatal

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2
Q

Is there a protective effect of C-section for HBV?

A

no

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3
Q

What percentage of infants with acute hepatitis B develop chronic hepatitis B?

A

> 90%

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4
Q

What percentage of immunocompetent adults with acute hepatitis B develop chronic hepatitis B?

A

< 5%

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5
Q

What is the genetic material of hepatitis B virus?

A

DNA

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6
Q

What specific tests should be ordered instead of ‘hepatitis B serology’?

A

HBsAg
HBcAb
HBsAb

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7
Q

What does HBsAg + indicate?

A

presence of surface antigen, indicates current infection

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8
Q

What does HbcAb + IgM indicate?

A

acute hepatitis B

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9
Q

What does HbsAb + indicate?

A

immunity

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10
Q

What does HBeAg + indicate?

A

active viral replication in patients with chronic hepatitis B

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11
Q

What does HBsAg -, HBcAb +, HBsAb + indicate?

A

quiescent HBV infection

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12
Q

What does HBsAg +, HBcAb +, HBsAB - indicate?

A

chronic HBV infection

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13
Q

What does isolated HBcAb + indicate?

A

distant quiescent HBV infection
false positive
resolving acute HBV infection
occult HBV infection

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14
Q

What tests should be ordered once you have diagnosed chronic HBV?

A

HBeAg, HBeAb, viral load, test for Hep A, Hep B, Hep D and HIV, LFTs, INR, AFP, FBE, liver US, fibroscan

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15
Q

When should hepatitis B be treated?

A

If HBeAg + -> when HBV DNA > 20,000 and elevated ALT

If HBeAg - -> when HBV DNA > 2000 and elevated ALT

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16
Q

What is the treatment for hepatitis B?

A

first line oral antivirals -> entecavir or tenofovir

17
Q

What should be done for liver cancer surveillance in chronic hepatitis B?

A

ultrasound +/- AFP every 6 months

18
Q

When should pregnant women with hepatitis B be treated?

A

Test viral load in 3rd trimester, if > 10&5 treat with tenofovir

19
Q

How should the babies of pregnant women with hepatitis B be treated?

A

Hep B immune globulin and vaccination within 12 hours of birth

20
Q

Is breastfeeding contraindicated in hepatitis B?

A

no, even if on tenofovir

21
Q

When should patients receiving immunosuppressive therapy be treated for hepatitis B?

A

Treat if HBsAg+ and moderate-high risk treatment

Also treat if HBsAg - but HBCAb + and high risk treatment

BPT Gastroenterology (11 decks)

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