Hepatitis B Flashcards

1
Q

What % of the world’s population has had HBV infection?

A

30%

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2
Q

What % of neonates, children and adults develop chronic infection?

A

95%, 20-30% and <5% respectively

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3
Q

What % of those infected seroconvert within a year?

A

10-20%

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4
Q

Which genotype is most associated with HCC?

A

Genotype C

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5
Q

What is a precore mutant?

A

HBeAg negative, increased risk of cirrhosis and HCC

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6
Q

What % of HBV-associated HCC develop without cirrhosis?

A

20%

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7
Q

Which drug combination is pangenotypic in HCV?

A

Sofosbuvir/Velpatasvir

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8
Q

When is risk of HBV infection becoming chronic at its highest?

A

At birth

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9
Q

What are the 4 stages of HBV infection and which stages receive active treatment?

A

Immune tolerance
Immune clearance - treat
Immune control
Immune escape - treat

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