Hepatitis B Flashcards
1
Q
What % of the world’s population has had HBV infection?
A
30%
2
Q
What % of neonates, children and adults develop chronic infection?
A
95%, 20-30% and <5% respectively
3
Q
What % of those infected seroconvert within a year?
A
10-20%
4
Q
Which genotype is most associated with HCC?
A
Genotype C
5
Q
What is a precore mutant?
A
HBeAg negative, increased risk of cirrhosis and HCC
6
Q
What % of HBV-associated HCC develop without cirrhosis?
A
20%
7
Q
Which drug combination is pangenotypic in HCV?
A
Sofosbuvir/Velpatasvir
8
Q
When is risk of HBV infection becoming chronic at its highest?
A
At birth
9
Q
What are the 4 stages of HBV infection and which stages receive active treatment?
A
Immune tolerance
Immune clearance - treat
Immune control
Immune escape - treat
