Hepatitis B Flashcards
What % of the world’s population has had HBV infection?
30%
What % of neonates, children and adults develop chronic infection?
95%, 20-30% and <5% respectively
What % of those infected seroconvert within a year?
10-20%
Which genotype is most associated with HCC?
Genotype C
What is a precore mutant?
HBeAg negative, increased risk of cirrhosis and HCC
What % of HBV-associated HCC develop without cirrhosis?
20%
Which drug combination is pangenotypic in HCV?
Sofosbuvir/Velpatasvir
When is risk of HBV infection becoming chronic at its highest?
At birth
What are the 4 stages of HBV infection and which stages receive active treatment?
Immune tolerance
Immune clearance - treat
Immune control
Immune escape - treat