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3. Conditions: Infection > Hepatitis > Flashcards

Hepatitis Flashcards

1
Q

How are each of the hep’s spread?

A 
Hep A = faecal oral
- Overseas seafood
Hep B = haem & vertical spread
Hep C = haem & less vertical spread
Hep D = haem (dependent on HBV co-infection)
Hep E = faecal oral
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2
Q

What type of virus is Hep A?

A

RNA virus

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3
Q

What are the symptoms of a prodromal Hep A infection?

A

Flu like
Anorexia

DISTASTE FOR CIGARETTES

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4
Q

What is the second phase of Hep A?

A

Icteric phase

  • HSM
  • Jaundice
  • Cholestasis
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5
Q

Investigations for Hep A?

A

LFTs
- ALT > AST but both raised

Immunoglobulins

  • IgM raised
  • Anti- HepA
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6
Q

Treatment of hep A?

A

Mostly supportive
- 85% recover fully

If fulminant hep

  • IFN-a
  • Liver transplant
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7
Q

What type of virus is Hep B?

A

DNA

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8
Q

What is the incubation time of Hep B?

A

1-6 months

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9
Q

What are the phases of Hep B infection?

A

Prodromal phase
Icteric phase
Immune complex formation

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10
Q

What are symptoms of prodromal phase?

A

Flu like symptoms

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11
Q

What are the symptoms of the icteric phase?

A

Jaundice
HSM
Cholestasis

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12
Q

What is the typical serological course of Hep B?

A

Initially

  • HBeAg raised
  • HBsAg rising
  • IgM anti-HBc rising the falling
  • Total anti-HBc rising

Later
- Detectable IgG anti-HBc

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13
Q

Which serological Hep B markers can be measured and what do each of them mean?

A

HBsAg
- current infection

HBcAg
- Active infection

IgM anti-HBc
- Current infection

IgG anti-HBc
- Past infection

Anti- HBs
- Immunisation

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14
Q

What are the symptoms of the immune complex phase in Hep B?

A

Urticaria
Polyarteritis nodosum
Glomerulonephritis

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15
Q

What serostatus of mother indicates a low risk of neonatal infection in Hep B?

A

HBsAg +ve

HBeAg -ve

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16
Q

What serostatus of mother indicates high risk of neonatal infection in Hep B?

A

HBsAg +ve

HBeAg +ve

17
Q

Treatment of Hep B?

A

Supportive
Pegylated interferon Ab2
Lamivudine

18
Q

Presentation of Hep C?

A

Usually asymptomatic

Icteric phase

19
Q

How does Hep C progress?

A

85% –> chronic infection

20% –> cirrhosis

20
Q

What does Hep C increase risk of?

A

Liver cancer

21
Q

Investigation for Hep C?

A

Anti-HCV antibodies
NAAT
Bloods
- LFTs

22
Q

What do LFTs indicate in Hep C?

A

Disease activity NOT prognosis

23
Q

Treatment of Hep C?

A

PEG Interferon

Ribavarin

24
Q

What type of virus is Hep B?

A

DNA virus

25
Q

What type of virus is Hep C?

A

Flavivirus

3. Conditions: Infection (18 decks)

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