Hepatitis Flashcards
1
Q
Antihepatitis Rx list
A
- Ribavirin
- Pegylated (Peg) Interferon
- Simeprevir (HCV protease block)
- Sofosbuvir (HCV Polymerase block)
- Ledipasvir (NS5A block)
2
Q
Ribavirin (HCV)
A
- guanesine analog, phophorylated internally by host cell
- Block viral RNA-dep polymerase
- +/- interfeuron
- TOX: Hemolytic anemia
3
Q
Interfeurons
A
*HVB/HCV RAMP UP IMMUNE SYSTEM *antiviral, immunomodulatory, antiproliferative *interfeuron alpha= stop viral penetration/translation/transcription/protein processing/maturation/release *UP histocompatibility antigens *UP macrophage phagocytosis *UP Cytotoxic T cells *direct effect on virus *TOX: flu-s/s
4
Q
Simeprevir
A
HCV PROTEASE INHIBITORS (NS3/4) (-PREVIR)
*TOX: Rash, Photosensitivity, P-glycoprotein transporter/CYP 3A4 inhibitor/substrate = Rx-Rx interactions
5
Q
Sofosbuvir
A
HCV POLYMERASE INHIBITOR (NS5B) Rna-dep RNA polymerase)
(-BUVIR)
*HCV pan-genotypic (1-6)
*STANDARD 1st LINE w/ ledipasvir/RBV/Peg
*can alone, w/ ledipasvir, w/ children (over 12)
*TOX: no w/ renal dysfunction
6
Q
Ledipasvir
A
NS5A PROTEIN INHIBITORS (-ASVIR)
- blocks replication
- HCV genotype 1
- only w/ Sofosbuvir
- CLOSEST CURE
- no need Peg/Ribavirin
- Ledipsavir/sofosbuvir
7
Q
Pan-genotypic
A
- Sofosbuvir
- Eplcusa
- Mavyret
8
Q
Cure
A
Finish tx 3 months (12 weeks) later no HCV = SVR 12
9
Q
Most common type
A
Type 1A
