Hepatitis

Question 1

what are Hepatitis treament class ?

Answer 1

• Nucleoside analogue (Lamuvidine,entacvir,Ribavirin)
• Nucleotide analogue(Adofovir,tenofovir,sobosfovir)
• Interferon

Question 2

what are treatment for HBV?

Answer 2

LEAT (Lamuvidine,Entacvir,Adofovir,Tenofovir)

Question 3

what is Ribavirin unique mechanism

Answer 3

Inhibit I-5-P-dehydrogenase –Converts Ionosine phosphate –>xanthine phosphate–>guanocine phosphate that incorporates into vira messanger RNA

Question 4

can adefovir and Tenofovir absorb orally

Answer 4

no, given in a prodrug form

Question 5

what are SE of Ribaviran

Answer 5

Could interfere with NRTI s

Also Hemolytic anemia and Hyperurecemia

Question 6

what are SE of Interferon ?

Answer 6

Alopecia in Children 
Dec plt and neutropenia
Neurotoxicity
Flu like Sx
Liver dysfunction

Question 7

what are types of interferon?

Answer 7

Interferon ar usauly given 3/week

Peglayted interferon given weekly due to long half lives Type 2 A and 2B available

Question 8

when should Zanamavir should be avoided ?

Answer 8

in Chronic airways disease

Question 9

what are drug classes for herpes infection?

Answer 9

Guanisine analogues (Acyclovir)
Viral DNA polymerase inhibitor

Question 10

how Acyclovir works ?

Answer 10

Viral kinase dervied from virus convert to Monophosphate form that converted to Tri phosphate form stoping replication
Some bacteria can develop resistance by mutating viral kinase

Question 11

SE of Acyclovir?

Answer 11

PO Minimal GIT only
IV neurotxic seizures,
Hypotention
nephrotoxic

Question 12

SE of Ganciclovir

Answer 12

BM supression
Neuro and nephrotoxic
Mucositis

Question 13

What are Viral DNA polymerase class?

Answer 13

CIDOFIVIR - Cellular kinase 2 p form
Foscarnet -Inhibit multiple enzymes
RT, DNA polymerase RNA dependent RNA polymerase

Question 14

SE of Cidofovir and Foscarnet?

Answer 14

Cidofovir–>Nephrotoxic given with probenicid

Foscarnet–> Elec abnormalities Ca Po4 and Mg