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Pathophysiology II > Hepatic pathophysiology > Flashcards

Hepatic pathophysiology Flashcards

1
Q

What is the basic functional unit of the liver?

A

lobule

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2
Q

About how many lobules are in the liver?

A

50,000-100,000

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3
Q

What 2 blood vessels bring blood to the liver?

A

portal vein and hepatic artery

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4
Q

What blood vessel brings blood out of the liver and where does that blood go?

A

hepatic vein, goes into IVC and returns to the heart

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5
Q

How much of the liver’s O2 requirement does the portal vein supply?

A

50-55%

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6
Q

What is the SaO2 of the portal vein?

A

85%

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7
Q

How much of the liver’ O2 requirement doe the hepatic artery supply?

A

45-50%

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8
Q

What is normal hepatic blood flow?

A

1,500 mL/min

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9
Q

How much of the body’s CO goes to the liver?

A

25-30%

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10
Q

About how many mL/min is delivered to the liver from the portal vein?

A

1100 mL/min

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11
Q

About how many mL/min is delivered to the liver from the hepatic artery?

A

400 mL

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12
Q

What is the portal vein pressure as blood enters the liver?

A

9 mmHg

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13
Q

What is the pressure in the hepatic vein as blood leaves the liver?

A

0 mmHg

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14
Q

The liver has (high/low) blood flow and (high/low) vascular resistance.

A

high blood flow, low vascular resistance

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15
Q

About how long does it take for blood to traverse from the portal vein to the central vein and why is this important?

A

8-9 seconds, allows sufficient time for the blood to be in contact with hepatocytes and Kupffer cells

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16
Q

What controls hepatic artery blood flow?

A

autoregulation based on metabolic demand

17
Q

What controls portal vein blood flow?

A

blood flow to the GI tract and the spleen

18
Q

What happens if there is a decrease in blood flow in one of the vessels that supplies blood to the liver?

A

change in blood flow from one source will produce a reciprocal (but somewhat limited) compensatory change in the blood flow from the other source Ex: dec. in hepatic artery blood flow produces an increase in portal venous blood flow

19
Q

What organs supply blood to the portal vein?

A 
stomach
spleen
pancreas
small intestines
colon
20
Q

How does cirrhosis affect blood flow through the liver?

A

greatly increases resistance to blood flow, destruction of liver parenchymal cells results in replacement with fibrous tissue that contracts around the blood vessels

Pathophysiology II (1 decks)

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