hepatic lipid modifiers

Question 1

statins

Answer 1

first line lower LDL
inhibit HMG CoA Reductase enzyme from performing the rate limiting step to synthesize cholesterol in hepatic cells

decreases cholesterol synthesis
increases LDL receptors
also has non lipid benefits (regression plaque size, improved endothelial function, stabilization of platelets, reduction of plasma fibrinogen, decreases inflammatory markers)

Question 2

Lipitor

Answer 2

atorvastatin, take anytime of day

CYP3A4

Question 3

Lescol XL

Answer 3

fluvastatin, take night time BID

CYP2C9

Question 4

Mevacor

Answer 4

Lovastatin take in evening

extensive CYP3A4

Question 5

Zocor

Answer 5

Simvastatin take in evening

extensive CYP3A4

Question 6

Crestor

Answer 6

Rosuvastatin take anytime of day

very low CYP2C9 metab

Question 7

Pravachol

Answer 7

Pravastatin take at night?

not metabolized

Question 8

Repatha

Answer 8

Evolocumab is an antibody to PCSK9 protein which degrades LDL receptors. this inhibits degredation of LDLR to help decrease plasma LDL

Question 9

Praluent

Answer 9

Alirocumab is an antibody to PCSK9 protein which degrades LDL receptors. this inhibits degredation of LDLR to help decrease plasma LDL