Heparins Flashcards
What are heparins commonly indicated for use in?
- VTE
- DVT
- PE
What is the mechanism of action of low molecular weight heparins?
Low molecular weight heparins inhibit the action of thrombin and factor Xa, but preferentially inhibit factor Xa.
What is the mechanism of action of unfractionated heparins?
Unfractionated heparin (UFH) activates antithrombin that, in turn, inactivates clotting factor Xa and thrombin
Why is LMWH preferred to unfractionated?
Requires no laboratory monitoring
What are important adverse effects of heparins?
- Bleeding
- Injection site reactions
- HIT
When should anticoagluants be used with caution?
What drugs can heparins interact with?
Warfarin
What are examples of LMWH?
- Enoxaparin
- Dalteparin
What do bloods do you need to do after commencing enoxaparin?
FBC - prior to treatment, and 1 week after
When taking FBC when monitoring heparin use, what are you looking for?
Decreased platelets - could indicate development of HIT
What should you do if someone is on heparin and develops thrombocytopenia?
Stop drug and seek specialist help immediately
How are heparins administered?
Subcutaneous injection
