Heparin Anticoagulants I Flashcards
1
Q
MOA of unfractionated heparin (UFH)?
A
complexes w/ AT and inhibits mainly factors Xa and IIa; monitored by APTT or anti-Xa assay
2
Q
MOA of LMWHs?
A
complex w/ AT and inhibit factors Xa and IIa; monitored by anti-Xa assay
3
Q
MOA of Fondaparinux (pentasaccharide)?
A
complexes w/ AT and inhibits factor Xa
4
Q
MOA of Argatroban?
A
directly inhibits IIa; excreted by liver; short HL
5
Q
MOA of Bivalirudin?
A
directly inhibits IIa; excreted by kidneys; short HL
6
Q
MOA of Hirudin?
A
directly inhibits IIa; excreted by kidneys; short HL
7
Q
MOA of antithrombin concentrate?
A
directly inhibits IIa
8
Q
MOA of protamine sulfate?
A
heparin antagonist (basic/pos agent that neutralizes acidic/neg UFH)
