Heparin Anti-coagulants

Question 1

Heparin MOA

Answer 1

Complex with Anti-thrombin (AT) and inhibits factors Xa and IIA. Monitored by APTT (2-2.5 baseline therapeutic)

Question 2

Heparin Route of Administration

Answer 2

Mainly intravenous and also given subcutaneous

Question 3

Heparin Indications

Answer 3

Surgical Anticoagulation

Question 4

Heparin Adverse Effects

Answer 4

Bleeding, osteoperosis, alopecia, HIT (Heparin Induced Thrombocytopenia)

Question 5

LMWHeparin MOA

Answer 5

Complex with Anti-thrombin (AT) and inhibits factors Xa and IIa. Monitored by anti-Xa

Question 6

LMWHeparin Route of Administration

Answer 6

Subcutaneous

Question 7

LMWHeparin Prophylaxis and Treatment of DVT and ACS

Answer 7

Bleeding

Question 8

Fondaparinux MOA

Answer 8

Complex with AT and inhibits Xa

Question 9

Fondaparinux Route of Administration

Answer 9

Subcutaneous

Question 10

Fondaparinux Indications

Answer 10

Management of DVT

Question 11

Fondaparinux Adverse Effects

Answer 11

Bleeding

Question 12

Argatroban MOA

Answer 12

Directly inhibits IIa

Question 13

Argatroban Route of Administration

Answer 13

Intravenous

Question 14

Argatrobran Indications

Answer 14

Anticoagulant management of HIT patients

Question 15

Argatroban Adverse Effects

Answer 15

Bleeding

Question 16

Bivalirudin MOA

Answer 16

Directly inhibits IIa

Question 17

Bivalirudin Route of Administration

Answer 17

Intravenous

Question 18

Bivalirudin Indications

Answer 18

Anticoagulant management of HIT patients

Question 19

Bivalirudin Adverse Effects

Answer 19

Bleeding

Question 20

Hirudin MOA

Answer 20

Directly inhibits IIa

Question 21

Hirudin Route of Administration

Answer 21

Intravenous

Question 22

Hirudin Indications

Answer 22

Anticoagulant management of HIT patients

Question 23

Hirudin Adverse Effects

Answer 23

Bleeding

Question 24

Antithrombin concentrate MOA

Answer 24

Directly inhibits IIa

Question 25

Antithrombin concentrate Route of Administration

Answer 25

Intravenous

Question 26

Antithrombin concentrate Indications

Answer 26

DIC, sepsis, thrombophilia, hypercoagulable state

Question 27

Antithrombin concentrate Adverse Effects

Answer 27

None

Question 28

Protamine Sulfate MOA

Answer 28

Heparin Antagonist

Question 29

Protamine Sulfate Route of Administration

Answer 29

Intravenous

Question 30

Protamine Sulfate Indications

Answer 30

Reversal for Heparin

Question 31

Protamine Sulfate Adverse Effects

Answer 31

Bradycardia, hypotension

Question 32

Warfarin MOA

Answer 32

Competitive antagonist of vitamin K. Suppresses the synthesis of functional forms of factors II, VII, IX, and X

Question 33

Warfarin Monitoring

Answer 33

PT/INR

Question 34

Warfarin Indications

Answer 34

Prolonged treatment of DVT and Atrial Fibrillation

Question 35

Warfarin Side Effects/Toxicity

Answer 35

Bleeding, coumadin induced necrosis (many interactions with drugs which leads to potentiation and resultant bleeding)

Question 36

Vitamin K MOA

Answer 36

Cofactor in the synthesis of functional forms of factors II, VII, IX, and X

Question 37

Vitamin K Indications

Answer 37

Hypothrombinemia, intestinal disorders, and gastrectomy, reverses effects of warfarin

Question 38

Vitamin K Side Effects

Answer 38

Hemolysis

Question 39

Oral Anti-Xa [Rivaroxaban/Apixaban] MOA

Answer 39

Inhibits factor Xa

Question 40

Oral Anti-Xa [Rivaroxaban/Apixaban] Indications

Answer 40

Stroke prevention in patients with AF | -Rivaroxaban also approved for prophylaxis and treatment of DVT

Question 41

Oral Anti-Xa [Rivaroxaban/Apixaban] Side Effects

Answer 41

Bleeding, liver toxicity

Question 42

Oral Antithrombin [Dabigatran] MOA

Answer 42

Inhibits thrombin

Question 43

Oral Antithrombin [Dabigatran] Indications

Answer 43

Stroke prevention in patients with AF

Question 44

Oral Antithrombin [Dabigatran] Side Effects

Answer 44

Bleeding, liver toxicity