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Cardio Block Exam > Heparin Anti-coagulants > Flashcards

Heparin Anti-coagulants Flashcards

1
Q

Heparin MOA

A

Complex with Anti-thrombin (AT) and inhibits factors Xa and IIA. Monitored by APTT (2-2.5 baseline therapeutic)

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2
Q

Heparin Route of Administration

A

Mainly intravenous and also given subcutaneous

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3
Q

Heparin Indications

A

Surgical Anticoagulation

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4
Q

Heparin Adverse Effects

A

Bleeding, osteoperosis, alopecia, HIT (Heparin Induced Thrombocytopenia)

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5
Q

LMWHeparin MOA

A

Complex with Anti-thrombin (AT) and inhibits factors Xa and IIa. Monitored by anti-Xa

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6
Q

LMWHeparin Route of Administration

A

Subcutaneous

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7
Q

LMWHeparin Prophylaxis and Treatment of DVT and ACS

A

Bleeding

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8
Q

Fondaparinux MOA

A

Complex with AT and inhibits Xa

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9
Q

Fondaparinux Route of Administration

A

Subcutaneous

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10
Q

Fondaparinux Indications

A

Management of DVT

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11
Q

Fondaparinux Adverse Effects

A

Bleeding

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12
Q

Argatroban MOA

A

Directly inhibits IIa

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13
Q

Argatroban Route of Administration

A

Intravenous

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14
Q

Argatrobran Indications

A

Anticoagulant management of HIT patients

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15
Q

Argatroban Adverse Effects

A

Bleeding

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16
Q

Bivalirudin MOA

A

Directly inhibits IIa

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17
Q

Bivalirudin Route of Administration

A

Intravenous

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18
Q

Bivalirudin Indications

A

Anticoagulant management of HIT patients

19
Q

Bivalirudin Adverse Effects

A

Bleeding

20
Q

Hirudin MOA

A

Directly inhibits IIa

21
Q

Hirudin Route of Administration

A

Intravenous

22
Q

Hirudin Indications

A

Anticoagulant management of HIT patients

23
Q

Hirudin Adverse Effects

A

Bleeding

24
Q

Antithrombin concentrate MOA

A

Directly inhibits IIa

25
Q

Antithrombin concentrate Route of Administration

A

Intravenous

26
Q

Antithrombin concentrate Indications

A

DIC, sepsis, thrombophilia, hypercoagulable state

27
Q

Antithrombin concentrate Adverse Effects

A

None

28
Q

Protamine Sulfate MOA

A

Heparin Antagonist

29
Q

Protamine Sulfate Route of Administration

A

Intravenous

30
Q

Protamine Sulfate Indications

A

Reversal for Heparin

31
Q

Protamine Sulfate Adverse Effects

A

Bradycardia, hypotension

32
Q

Warfarin MOA

A

Competitive antagonist of vitamin K. Suppresses the synthesis of functional forms of factors II, VII, IX, and X

33
Q

Warfarin Monitoring

A

PT/INR

34
Q

Warfarin Indications

A

Prolonged treatment of DVT and Atrial Fibrillation

35
Q

Warfarin Side Effects/Toxicity

A

Bleeding, coumadin induced necrosis (many interactions with drugs which leads to potentiation and resultant bleeding)

36
Q

Vitamin K MOA

A

Cofactor in the synthesis of functional forms of factors II, VII, IX, and X

37
Q

Vitamin K Indications

A

Hypothrombinemia, intestinal disorders, and gastrectomy, reverses effects of warfarin

38
Q

Vitamin K Side Effects

A

Hemolysis

39
Q

Oral Anti-Xa [Rivaroxaban/Apixaban] MOA

A

Inhibits factor Xa

40
Q

Oral Anti-Xa [Rivaroxaban/Apixaban] Indications

A

Stroke prevention in patients with AF

-Rivaroxaban also approved for prophylaxis and treatment of DVT

41
Q

Oral Anti-Xa [Rivaroxaban/Apixaban] Side Effects

A

Bleeding, liver toxicity

42
Q

Oral Antithrombin [Dabigatran] MOA

A

Inhibits thrombin

43
Q

Oral Antithrombin [Dabigatran] Indications

A

Stroke prevention in patients with AF

44
Q

Oral Antithrombin [Dabigatran] Side Effects

A

Bleeding, liver toxicity

Cardio Block Exam (5 decks)

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