Hep C

Question 1

genotype with worse prognosis

Answer 1

genotype 1
there are 6

Question 2

transmission

Answer 2

via exchange of blood and bodily fluids
- IV drug use
- blood transfusion
- haemodialysis
- sexual transmission
- needlestick injuries
- parinatal from infected mother

Question 3

presentation and chronic status

Answer 3

most are asymptomatic
75% develop to chronic
cirrhosis 20-30%

Question 4

investigations

Answer 4

• GOLD STANDARD HCV RNA PCR - shows levels - if high then high, low then r=decreasing - + for more than 2 months need to be treated
• enzyme immunoassay IgG
• recombinant immunoblot - high sensitivity low specificity

Question 5

management

Answer 5

drug therapy considered for all patients
- direct acting antiviral therapy
- nucleoside analogs preferred - sofosbuvir
- antivirals

Question 6

vaccine?

Answer 6

no

Question 7

genome

Answer 7

flavivirus ssRNA