Henoch-Schönlein Purpura PBL Flashcards by Robbie Gruhl | Brainscape

Q

Henoch-Schönlein Purpura

population affected

A

< 10 y/o

(90% of cases)

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Q

When is HSP most common (time of year)

A

during winter

might be due to association post-viral illness

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Q

HSP precipitating event

A

post-viral illness

anything that can cause increase in sIgA

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Q

Histologic signs of IgA vasculitis

A

leukocytoclastic vasculitis

± fibrinoid necrosis

perivascular IgA deposition

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Q

Leukocytoclastic defintion

A

refers to nuclear remenents left from neutrophilic infiltration

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Q

Renal Bx findings

A

crescents: 2+ layers in glomerulus

mesangial IgA deposition

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Q

If you have crescents, you might get this disease

A

rapidly progressive glomerulonephritis

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Q

Crescents on renal Bx mean…

A

TREAT

cyclosporin and corticosteroids

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Q

Main pathophysiology in HSP

A

type III hypersensitivity

IgA deposition (post-viral illness)

causes necrosis where deposited

⇒ vasculitis and glomerulonephritis

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Q

A

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