Henoch-Schonlein Purpura (HSP) Flashcards
What type of vasculitis is HSP?
IgA-mediated small vessel vasculitis
Which age group is most affected by HSP?
2-11
What commonly precedes HSP?
Infection (usually GAS) 1–3 weeks prior
Where is the typical HSP purpuric rash located?
Buttocks and lower limbs
What are key GI symptoms of HSP?
Colicky abdominal pain, bloody diarrhoea
What joints signs are seen in HSP?
Joint pain and swelling
What is the hallmark renal finding in HSP?
Haematuria, may progress to IgA nephropathy
What is the key finding on blood tests for HSP?
Elevated IgA
What bedside test is essential in HSP assessment?
Urine dipstick (for haematuria/proteinuria)
How is HSP usually managed?
Supportive—self-limiting in 8 weeks
What long-term monitoring is needed in HSP?
Urinalysis and BP to check for renal involvement
Which antibodies are found in the immune complexes deposited in the affected blood vessels in Henoch Schonlein Purpura?
IgA
A 5-year-old boy presents with a 3-day history of severe abdominal pain, painful knees, and a purple rash on his legs and buttocks. He is drinking but not eating much, has normal bowel movements, and brownish urine. He denies vomiting, diarrhoea, headache, neck stiffness, or photophobia. He had a cold 2 weeks ago and is up to date on vaccinations.
He appears well but in pain. Vital signs: RR 20, O2 99%, HR 82, capillary refill 2 seconds, BP 122/76, temperature 37.1°C. A purpuric rash is present on the legs and buttocks. What is the mechanism of this child’s condition?
Small vessel vasculitis
A 3-year-old boy is brought to the paediatric emergency department by his father. His father is concerned as he has developed a pinprick purple rash on the back of his legs and has been complaining of stomach and knee pain for the last few days. Before this, he had a cold.
His vital signs are normal.
What is the most appropriate management of this condition?
NSAIDS
A 13-year-old girl develops purpura on her lower limbs and buttocks associated with microscopic haematuria. A diagnosis of Henoch-Schonlein purpura is made. Her urea and electrolytes show mild renal impairment that is still present 4 weeks later, although she does not require any specific therapy
What is the most likely renal outcome?
Full renal recovery
