Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

apa2 > hemostasis > Flashcards

hemostasis Flashcards

1
Q

the process of hemostasis involves what 4 things?

A

vessel wall,
platelets,
coagulation cascade,
fibrinolytic system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

cell based theory of coagulation

A

posits that coagulation occurs on different cell surfaces that contain tissue factor (TF)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

vessel structure of arteries and veins

A 
tunica adventia(outer),
tunica media,
tunica intima
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

vessel structure of capillaries

A

single layer of endothelial

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

endothelial cells synthesize and secrete

A

procoagulants,
anitcoagulants,
fibrinolytics (vWF, tissue factor, NO, prostacyclin, thromboxane a2, ADP, tissue factor pathway inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

the tunica intima (endothelial layer) forms a barrier separating fluid contents within the blood vessel from the highly ________ material that lies in the tunica media

A

thrombogenic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

necessary cofactor for adherence of platelets to the subendothelial layer

A

Von Willebrand factor (vWF)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Activates the clotting cascade pathway when injury to the vessel occurs

A

tissue factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

endothelial cells- vasoconstriction

A

thromboxane A2,
Adenosine diphosphate (ADP),
Setotonin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

endothelial cells- vasodilation

A

nitric oxide,

prostacyclin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

endothelial cells- coagulation inhibitors

A

tissue factor pathway inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

extremely thrombogenic, very active, collagen and fibronectin

A

tunica media-subendothelial

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

control of blood flow by influencing the vessel’s degree of contraction via vasodilation by: NO, Prostacyclin

A

tunica adventitia- third layer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Mediators of intima

A

vWF,
tissue factor,
prostacyclin,
nitric oxide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

mediators of media layer

A

collagen and fibronectin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

mediators of adventitia

A

nitric oxide and prostacyclin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

procoagulant mediators

A

collagen, vWF, and fibronectin (coagulation factors, protein c and s, thrombomodulin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

collagen function

A

tensile strength

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

vWF function

A

adhesion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

protein c function

A

degrades factors v and VII

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

protein s function

A

cofactor for protein c

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

fibronectin function

A

mediates cell adhesion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

thrombomodulin function

A

regulates anticoagulant pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

anticoagulant mediators

A

antithrombin II and tissue pathway factor inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Antithrombin II function

A

degrades factors XII, XI, X, IX, II

26
Q

tissue pathway factor inhibitor function

A

inhibits tissue factor

27
Q

vasodilation mediators

A

nitric oxide and prostacyclin

28
Q

prostacyclin function

A

vasodialates, inhibits aggregation (both prostacyclin and NO promote smooth-muscle relaxation)

29
Q

vasoconstriction mediators

A

thromboxane A2, ADP, and serotonin

30
Q

Fibrinolytic mediators

A

plasminogen, tPA, and urokinase

31
Q

Plasminogen function

A

converts to plasmin

32
Q

tPA and urokinase functions

A

activates plasmin

33
Q

antifibrinolytic mediators

A

plasminogen activator inhibitor, and a-antiplasmin

34
Q

plasminogen activator inhibitor function

A

inactivates tPA, urokinase

35
Q

a-Antiplasmin function

A

inhibits plasmin

36
Q

Essential component to the thrombogenic response,

round, disk like, circulate freely in the blood

A

the Platelet

37
Q

Where is the platelet formed?

A

in the bone marrow

38
Q

Daily use of plts by body

A

7.1x10^3 (7,100)

39
Q

platelet cell characteristics

A

contain mitochondria, glycogen stores,

contractile proteins, calcium, enzymes

40
Q

alpha granules

A 
vWF, 
fibrinogen,
fibronectin,
platelet factor 4,
platelet growth factor, (VFFPP)
41
Q

Dense granules

A 
Serotonin,
ADP,
ATP,
Histamine,
Epinephrine
42
Q

Do platelet cell produce thrombin?

A

yes, activates coag factors and influence recruitment of platelets

43
Q

Do platelets have a nucleuse, RNA, DNA?

A

NO

44
Q

T/F: Plts are inactive unless activated as a result of tissue trauma

A

TRUE

45
Q

IS adequate hemostasis possible in the absence of activated platelets?

A

NO

46
Q

formation of plug involves

A

adhesion, activation, aggregation

47
Q

adhesion involves

A

vWF mobilizes from endothelial cells, glycoprotein Ib receptors emerge from surface of platelet. GpIb attaches to vWF and attracts additional plts to the endothlial lining while vWF makes plts “sticky”

48
Q

What causes the platelt to undergo a conformational change and become________

A

tissue factor “activated”

49
Q

What are the little cell feet activated platelets show?

A

pseudopodia

50
Q

When the GpIIb-IIIa receptor complex links activated platelets together to form a primary platelet plug, this is known as?

A

aggregation

51
Q

As plts undergo this “activation” process they release _____ and _____ granules, contractile granules, thrombin, and procoagulant mediators into the blood.

A

alpha and dense

52
Q

coagulation cofactors are known as

A

zymogens

53
Q

cofactors are enzymes with the exception of factor __ and ___ and circulate in an inactive state until activated

A

V and VIII

54
Q

Factor I: name, synthesized, vit k dep, action

A

fibrinogen,
Liver,
No vit k,
Forms a clot

55
Q

Factor II: name, synthesized, vit k dep, action

A

Prothrombin,
Liver,
Yes vit k,
when activated, activates I,V,, VII, XIII, plts, and protein C

56
Q

Factor III: name, synthesized, vit k dep, action

A

Tissue Factor or Thromboplastin,
Vascular wall and extravascular cell membranes, released from traumatized cells,
Cofactor of VII

57
Q

Factor IV:name, synthesized, vit k dep, action

A

Calcium,
Diet,
Promotes clotting reactions

58
Q

Factor V: name, synthesized, vit k dep, action

A

Proaccelerin, Liver,
No vit k,
Cofactor of X, forms a prothombinase complex

59
Q

Factor VII: name, synthesized, vit k dep, action

A

Proconvertin,
Liver,
YEs vit k,
Activates IX and X

60
Q

Factor XIII: name, synthesized, vit k dep, action

A

Antihemophiliac,
Liver,
No vit k,
Cofactor to IX

apa2 (3 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions