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Inf Dz > Hemorrhagic virals > Flashcards

Hemorrhagic virals Flashcards

1
Q

What does all hemorrhagic viruses have in common?

A

Damage microvasculature leads to INC permeability

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2
Q

Mosq, Truncal rash, LAD, Tourniquet test indicates

A

DF (DHF or DSS)

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3
Q

HF involving Ticks/livestock?

A

Crimean/Congo HF

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4
Q

What does a saddleback fever mean and for what infection?

A

Fever abates for a day then returns and it means this is the time you can develop DHF or DSS
YF transfers from acute to remit (1d) to toxic phase

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5
Q

Is there a vaccine available for yellow fever?

A

Yes 1937

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6
Q

How many serotypes of Dengue are there?

A

4 (DEN-2 most virulent)

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7
Q

How long is E/M recovery?

A

months

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8
Q

TXT Lassa w/

A

Ribavirin w/in 6D

aggressive support

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9
Q

TXT Hantavirus w/

A

Fluids/Lytes
Support
RIbavarin

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10
Q

3 phases of YF

A

Acute (3D)
Remit (1D - saddleback)
Toxic phase

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11
Q

How often to monitor HCT w/ DF?

A

Q3-4hr

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12
Q

Are humans a natural reservoir for VHFs?

A

No

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13
Q

Swollen baby syndrome is due to what infection and causes what?

A

Lassa

Edema, Dist Abd, Anascara, Bld

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14
Q

Saddleback fevers suggest

A

Dengue and yellow fever

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15
Q

TXT E/M consist of

A

isolation
support- fluids and nutrition
human convalescent plasma

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16
Q

Flaviviridae

A

Dengue

Yellow Fever

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17
Q

Are hemorrhagic fever viruses DNA or RNA?

A

RNA

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18
Q

Where does the YF virus replicate?

A

Overwhelms immune sys by Reticuloendothelial sys affecting liver (jaundice)

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19
Q

What is the Tourniquet test for and how is it performed?

A

To test Dengue fever

Inflate BP cuff in upper arm between SBP and DBP and hold for 5m. POS= 20 petechiae per square inch

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20
Q

What are important lab findings of E/M?

A

Metabolic acidosis and INC Bun/Creatinine

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21
Q

Complications of Lassa

A

Fetal/maternal mortality

Deafness (MC)

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22
Q

What precedes shock w/ DF?

A

Rise in HCT by 20 percent

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23
Q

What are a common PE findings of E/M?

A

INC HR and RR

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24
Q

Ghost like faces is a late finding of what infection?

A

E/M

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25
Q

Two forms of yellow fever are?

A

Urban - Aedes Aegypti mosq (epidemic)

Jungle - various mosq

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26
Q

Rodent resvoir and an ass/w deafness or fetal/maternal complications indicates?

A

LASSA

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27
Q

What labs are low w/ DF

A

WBC - end of febrile phase
PLT
Na (MC- metabolic change)
Albumin - Sign of hemoconc

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28
Q

The significance of HCT w/ DF

A

INC 20 percent = hemoconcentration = oozing plasma

DEC 10 percent = significant hemorrhage = bleeding

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29
Q

Important S/S of CCHF

A

Flu like then massive hemorrhage/bruising

Substantial GI bleeding

30
Q

Important E/M S/S

A

Rash over entire body
Diarrhea
Odynphagia/Dysphagia

31
Q

Bats, Primates, Rash over body, difficulty swallowing indicates

A

E/M

32
Q

INC WBC and HCT and K w/ DEC PLT and Na suggests

A

Hantavirus

33
Q

TXT DF

A

Self limit (APAP for fever)

34
Q

Complications of E/M

A

ocular issues, tinnitus, unilat orchitis

35
Q

Arenaviridae

A

Lassa fever

36
Q

Bunyaviridae virus strains

A

Crimean-Congo HF

Hantavirus

37
Q

Dx Lassa

A

IgG/IgM ELISA

PCR

38
Q

Trias of hanta virus

A

Fever
Hemorrhage
Renal insuff

39
Q

Flu like, ticks, and bruising indicates

A

CCHF

40
Q

TXT/PVT YF

A

support, central vein access
FFP for active bleeds
vaccine and deet

41
Q

Black water (BIlious) vomiting indicates

A

Membrane/GI bleed of Yellow fever

42
Q

TXT CCHF is

A

Ribavirin

43
Q

What labs are ABNL with Lassa

A

AST is high

DEC Lymph/PLT

44
Q

Rodent resivoir and an ass/w Asia or Renal insuff indicates

A

Hantavirus

45
Q

Filoviridae

A

Ebola

Marburg

46
Q

What does rash of DF look like?

A

Truncal Scarlatinaform rash/maculopapular

47
Q

Mosq, black water/bilious vomit, w/ cardiac/AMS changes indicates?

A

YF

48
Q

Important DF S/S

A

Truncal rash
Retro-orbital pain
Very high fever
General LAD

49
Q

DX E/M

A

IgG/IgM Elisa or PCR

50
Q

What can a baby get if Lassa is contracted?

A

Swollen baby syndrome

51
Q

Hiccups is an indicator of what with what infection?

A

Indicates high mortality for E/M

52
Q

5 stages of HFRS

A 
Febrile - bradycardic
HOTN - tachycardic and shock w/ paralytic ileus
Oliguric - HTN, uremia causing bleedsing
Diuretic - rapid deyhdration
Convalescent - 3-6mo
53
Q

Complication of CCHF is

A

Encephalitis (rare)

54
Q

Type of mosquito spreads Dengue Fever?

A

Aedes Aegypti (Albopictus) Day-bites

55
Q

Best way to PVT dengue is?

A

20-30% Deet

56
Q

Is bleeding common with LASSA?

A

No (rare)

57
Q

Important S/S of yellow fever

A

Bilious black water vomiting (acute)

AMS and cardiac changes (toxic)

58
Q

Complications of hantavirus

A

Pulm Edema and hypercalcemia

59
Q

HF commonly found in Asia

A

Hantavirus

60
Q

Are there cures for VHFs?

A

No

61
Q

What does the Rash of E/M look like?

A

Maculopapular rash over entire body

62
Q

Important adult S/S of Lassa

A

Insidious onset
lumbar pain
cough
facial/neck edema

63
Q

Ribavirin is used to TXT what

A

LASSA
Hantavirus
CCHF

64
Q

TXT for DHF or DSS

A

IV fluids
Bld transfusion (Whole blood)
Gamma globulin

65
Q

What is ZMAPP?

A

Experimental drug used for E/M

66
Q

What are the forms of Dengue?

A

D. Fever - Asymp/symp (?)
D. Hemorrhagic fever
D. Shock Syndrome

67
Q

Resvoir for Ebola/marburg?

A

Bats (MC) and primates

68
Q

Dx DF

A

Viral Cx
Serology - IgG or IgM(D5 to 3months)
PCR - test during 1st week

69
Q

What infection is related to rodent to human transmission?

A

Lassa

70
Q

HF ass/w renal insuff

A

Hantavirus

71
Q

What is the resivoir of hantavirus?

A

Rodents (lassa has no renal issues)

Inf Dz (2 decks)

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