Hemopoiesis

Question 1

What is hemopoiesis

Answer 1

This is the development, differentiation and formation of blood cellular components

Question 2

Hemopoietic sites

Answer 2

Mesoblastic stage : 2nd week iul- 3rd month
Occurs in the yolk sac

Hepatic stage : 2nd month- 7th month
Occurs in the liver

Myeloid stage: 6th month- adult
Occurs in the bone marrow

Question 3

Hemopoietic marrow in adults

Answer 3

Central skeleton ( skull, spine, thoracic cage, iliac crest)

Proximal ends of femur and humeri

Question 4

Stages of hemopoietic cell dev.

Answer 4

Hemopoiesis begins with a stem cell
The stem cell can either undergo self renewal or differentiation

Differentiation- lineage selection- physical maturation- functional maturation- death

Question 5

The hemopoietic stem cell morphologically resembles

Answer 5

A small lymphocyte

Question 6

The hemopoietic stem cell morphologically resembles

Answer 6

A small lymphocyte

Question 7

Immunological testing
Stem cell is postive for

Answer 7

-cd34
-ac133
-thy-1
-c-kit

Question 8

Immunological testing
Stem cell is negative for

Answer 8

• cd33
  -cd38
• lineage markers
• hla-dr

Question 9

Stem cell plasticity

Answer 9

This refers to pluripotent stem cells and their ability to generate different types of tissues.

Question 10

How many stem cells do humans have

Answer 10

Humans possess 2104 stem cells

Question 11

How many stem cells do humans have

Answer 11

Humans possess 2104 stem cells

Question 12

How many stem cells do humans have

Answer 12

Humans possess 2104 stem cells

Question 13

Bone marrow component

Answer 13

Stromal cells and micro vascular network

Question 14

Bone marrow component

Answer 14

Stromal cells and micro vascular network

Question 15

Bone marrow component

Answer 15

Stromal cells and micro vascular network

Question 16

Stromal cells contain

Answer 16

Adipoctyes, macrophages, fibroblasts and endothelial cells

Question 17

Characteristics of progenitor cells

Answer 17

• loss of pluripotency
• ## lack of capacity for self renewal

Question 18

Existence of progenitor cells

Answer 18

Using in vitro culture
Early progenitors- assayed using bone marrow stroma

Late progenitors- assayed using semi-solid media

Question 19

Precursors of erythropoiesis

Answer 19

• proerythroblast
• basophilic erythroblast
  -polychromatic erythroblast
• orthochromatic erythroblast
• reticulocyte
  Erythrocyte