Hemophilus influenza

Question 1

Disease

Answer 1

Meningitis in young child.
Upper respiratory tract infection(Otitis media,Sinusitis,Conjunctivitis, Epiglottitis) and sepsis in child.
Pneumonia in adults.

Question 2

Properties

Answer 2

Small,Pleomorphic
Gram -ve coccobacilli
Have polysaccharide capsule
Six serotypes (a-f)
Need factor X(Heme) and Factor V(NAD)
Vaccine:Type B Capsular polysaccharide

Question 3

Causes of meningitis in Neonate

Answer 3

Group B streptococci (dysgalactiae?agactiae??)
Listeria monocytogens
G-ve bacilli(E.Coli,Proteus)

Question 4

Causes of meningitis in Pre-School child

Answer 4

Hemophilus influenza
Neisseria meningitidis
Streptococcus pneumoniae

Question 5

Causes of meningitis in older child and adult

Answer 5

Neisseria meningitidis
Streptococcus pneumonia

Question 6

Reservoir

Answer 6

Human

Question 7

Route

Answer 7

Inhalation of airborne droplet

Question 8

Disease by encapsulated strain

Answer 8

Meningitis

Question 9

Disease by non encapsulated strain

Answer 9

Otitis media
Sinusitis
Pneumonia

Question 10

Age

Answer 10

6 months to 6 years
Peak in 6 months to 1 year

Question 11

Why young child?

Answer 11

Decrease in maternal igG
Inability to generate sufficient antibody until age of 2 years

Question 12

Lab diagnosis

Answer 12

Gram stain
Chocolate agar(75°C)
Quellung reaction
Serology(latex agglutination,Immunoelectrophoresis)
PCR