Hemolymphopoietic Growth Factors/ Cytokines

Question 1

ERYTHROPOIETIN

-Biologic Effect

Answer 1

ERYTHROPOIETIN

Biologic Effect: erythrocyte production

Question 2

INTERLEUKIN-3

• Other names
• Biologic Effect

Answer 2

INTERLEUKIN-3

Other names:

• Multi-colony-stimulating factor
• Stem cell activating factor
• Persisting cell-stimulating factor
• Hemopoietin-2

Biologic effect:
–>Stimulates proliferation and differentiation of granulocyte, macrophage, eosinophil, mast cell, megakaryocytic, T- and B-cell lineages, and earlymyeloid stem cells

–> Interacts with erythropoietin to stimulate erythroid colony formation

–> Stimulates proliferation of AML blasts

–> Stimulates proliferation of mature macrophages, histamine release by mast cells, and eosinophil killing of schistosome manson larvae

Question 3

GRANULOCYTE-COLONY STIMULATING FACTOR (G-CSF)

• Other names
• Biologic effect

Answer 3

GRANULOCYTE-COLONY STIMULATING FACTOR (G-CSF)
Other names:
–>Differentiation factor
–> MGI-2