Hemoglobin & Myoglobin Flashcards
_____ is a complex of protoporphyrin IX and ferrous ion (Fe2+)
Heme
What does heme do in hemoglobin and myoglobin?
it serves to reversibly bind oxygen
Where is Myoglobin present?
Heart and skeletal muscle
What is the function of myoglobin?
reservoir of oxygen in red muscle fibers
When is the oxygen that is stored in myoglobin released?
During oxygen deprivation
Does myoglobin have a high or low molecular weight?
Low ~17,000
Where is Hemoglobin present?
in RBCs
What is the function of Hemoglobin?
it reversibly carries oxygen from lungs to peripheral tissues, and H+ and some CO2 from peripheral tissues to the lungs.
HbA has what?
2 alpha, 2 beta
HbF has what?
2 alpha, 2 gamma
HbA2 has what?
2 alpha, 2 delta
How long does embryonic hemoglobin persist?
from 15 days after fertilization until 6 weeks of embryonic life
When does HbF predominate?
from 6 weeks of fetal life; gradually falls from 30 weeks of prenatal life. At birth and up until 4-5 weeks of post natal life, HbF is the predominate type.
When completely saturated, how many oxygens do myoglobin and hemoglobin bind?
myoglobin binds one O2 and hemoglobin binds 4
In the absence of oxygen (T form), the interaction between (αβ)1- (αβ)2 is ______
tight