Hemoglobin

Question 1

Hb to HbO2

Answer 1

1. Fe atom moves into plane of heme
His F8 moves
F helix moves
2. b Tyr HC2 (145) expelled from pocket
near C-terminus interchain salt link
3. intersubunit salt link breaks: 
b C-terminus ---- a Lys C5
4. b His HC3 (146) moves (neg (Asp)  pos)
pK : H+ released [1/3 Bohr effect]
5. b subunits move together  BPG expelled