hemodynamics part 4 Flashcards
what are the effects of turbulence
- causes endothelial injury or dysfunction (disruption of normal laminar flow)
- Forms countercurrents causing local pockets of stasis
- -> disrupts laminar fluid
- -> prevent dilution of clotting factors
- -> prevent inflow of clotting inhibitors
- -> promote endothelial cell activation
what are the causes of tubulent blood flow
- ulcerated atherosclerotic plaque
- aneurysm
- myocardial infarction
- mitral valve stenosis –> rheumatic fever
- atrial fibrillation
- hyperviscosity syndrome –> polycythemia
- sickle cell anemia
what are some molecules that maintain shear stress (laminar flow)
- Many antithombotic agents (NO, prostacylin, tissue plasminogen activator, thrombomodulin)
- antimigration agents like NO
describe thrombi morphology
- occur anywhere in cardiovascular system
- arterial thrombi usually occur at sites of ENDOTHELIAL INJURY
- venous thrombi usually occur as a consequence of stasis (LOW FLOW)
- thrombi have a point of firm attachment to the vessel
what are the complications of arterial thrombosis
- may cause local obstruction or distant embolization
- risk factors include:
- -> myocardial infarction
- -> rheumatic heart disease
- -> atrial fibrillation
- -> atherosclerosis
What are arterial thrombi composed of
- composed of:
- -> platelets
- -> fibrin
- -> erythrocyte
- -> leukocytes
describe abdominal aortic aneurysm
- ruptured AAA mortality rate is 75%
- usually seen in older people
- stenting or surgery recommended for aneurysms greater than 5cm in diameter
- Out-pouching of the wall
define lines of Zhan in a thrombus
- alternate layering of platelets, fibrin and erythrocytes
Describe venous thrombi
- usually due to stasis
- -> contain more erythrocytes and therefore are red
- Mostly occur in lower extremity veins but may involve other less common sites
- Thrombi START forming in the valve pockets of the deep vein
- 50% of affected patients are asymptomatic
what are the risk factors of venous thrombosis
- CHF
- Trauma
- surgery
- pregnancy
- cancer
- -> trousseau syndrome/migratory thrombophlebitis
define Trousseau syndrome/migratory thrombophlebitis
- a serine protease released by malignant tumor cells activates factor 10
- tumor cells release plasma membrane vesicles exhibiting procoagulant activity
- tissue thromboplastin is released from necrotic tumor
what is the fate of a thombus
- resolved (resolution)
- embolization to lungs
- organized and incorporated into wall of vessel
- organized and recanalized
- propagate towards heart (grow)
define embolus
- a detached intravascular solid, liquid or gaseous mass that is carried by the blood to a site distant from its point of origin
- emboli travel until they become lodged in a vessel too small for further migration to occur
- tissues distal to this blockage are at risk for infarction
what are the sources of arterial emboli
- atrial fibrillation
- mitral stenosis
- endocarditis
- mural thombi in heart or aorta
- paradoxical emboli
where do most embolism end up
lower extremities
Define mural thombi
- arterial thombosis in cardiac chambers due to myocardial infarction, ulcerated atherosclerotic plaque or aneurysmal dilatation
define paradoxical embolism
- rare condition in which an embolus originating from the venous circulation passes through an inter-atrial or inter-ventricular defect to gain access to the systemic circulation
- usually go to the leg, can go to brain
define pulmonary thromboembolism
- 95% arise from deep leg vein thrombi above level of knee
- 200,000 deaths per year in the U.S.
- Pulmonay embolus may…
- -> occlude main pulmonary artery
- -> lodge across vessel bifurcation (saddle embolus) (sudden death)
- -> occlude smaller branching arterioles
what is the result of large emboli
- occlude major arteries, “saddle emboli”, sudden death or acute right heart failure
what is the result of medium sized emboli
- occlude medium-sized branches;
- more likely cause infarction;
- seen mainly in patients with heart or lung disease
- causes wedge like infarct in lung
What is the result of small emboli
- 60-80%
- cause occlusion of peripheral vessels
- mostly SILENT
- infarctions only if compromised pulmonary circulation
- hemorrhages mainly
what is the result of recurrent emboli
- 3% of cases
- pulmonary hypertension
- chronic cor pulmonale (right heart failure)
- worsening dyspnea
describe fat embolism
- fat globules in the circulation are common due to:
- -> fractures of long bones
- -> soft tissue trauma
- -> burns
- 90% of people are unaffected
Describe fat embolism syndrome
- 10% of people with fat emoblisms
- 1-3 days after injury
- tachypnea and dyspnea
- tachycardia
- irritability/restlessness.coma
- diffuse petechial rash
- pulmonary insufficiency