Hemodynamics and Shock Flashcards

1
Q

classic definition of hypotension

A

SBP <90 mmHg or decrease of 40 mmHg from baseline

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2
Q

end organ dysfunction in shock manifestation in CNS

A

encephalopathy and cortical necrosis

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3
Q

end organ dysfunction in shock manifestation in cardiac

A

tachycardia/bradycardia, ventricular ectopy, myocardial ischemia/depression

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4
Q

end organ dysfunction in shock manifestation in pulmonary

A

acute respiratory failure and acute respiratory distress syndrome

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5
Q

end organ dysfunction in shock manifestation in renal

A

pre renal insults, AKI, ATN

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6
Q

end organ dysfunction in shock manifestation in GI

A

erosive gastritis, ileus, pancreatitis

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7
Q

end organ dysfunction in shock manifestation in hepatic

A

ischemic hepatitis, cholestasis, “shock” liver

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8
Q

end organ dysfunction in shock manifestation in hematologic

A

disseminated intravascular coagulation (DIC), dilution thrombocytopenia

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9
Q

end organ dysfunction in shock manifestation in metabolic

A

hyperglycemia, glycogenolysis, glyconeogenesis, hypoglycemia (late), hypertriglyceridemia

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10
Q

end organ dysfunction in shock manifestation in immune system

A

gut barrier function, cellular and humoral immunity depression

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11
Q

cardiovascular clinical presentation

A

-cardiac index <2.2 L/min/m^2
-SBP <90 or MAP <65 mmHg

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12
Q

tissue hypo perfusion clinical presentation

A

-cold, clammy, mottled skin
-lactate >2 mmol/L
-Scvo2 <65% or Svo2 <60%

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13
Q

organ dysfunction clinical presentation

A

-encephalopathy, lethargy, confusion
-liver dysfunction
-urine output <0.5 mL/kg/hr

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14
Q

blood pressure calc

A

BP = CO x SVR

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15
Q

cardiac output calc

A

CO = HR x SV

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16
Q

mean arterial pressure (MAP) calc

A

MAP = 1/3 SBP + 2/3 DBP

ex: 90/60 = 70 mmHg

17
Q

goals for hemodynamic shock

A

-MAP > 65 mmHg
-lactate <2 mmol/L
-HR <100 bpm

18
Q

central venous catheter (CVC)

A

-measures Scvo2
-admin: fluids, pressors, antimicrobials, parenteral nutrition

19
Q

arterial line

A

measures MAP, SBP/DBP, ABG

20
Q

types of shock

A

hypovolemic, distributive, cardiogenic, obstructive

21
Q

hypovolemic shock presentation

A

↓ PCWP, ↓ CO, ↑ SVR, ↓ Svo2

22
Q

cardiogenic shock presentation

A

↑ PCWP, ↓ CO, ↑ SVR, ↓ Svo2

23
Q

distributive shock presentation

A

↓ PCWP, ↓↑ CO, ↓ SVR, ↓↑ Svo2

24
Q

obstructive shock presentation

A

↑ PCWP, ↓ CO, ↑ SVR, ↓ Svo2

25
hypovolemic shock
inappropriately low and sudden loss of intravascular volume from hemorrhage or GI losses
26
hypovolemic shock management
hemorrhage: replace blood! (PRBC) GI losses/burns: fluids
27
cardiogenic shock
failure of left ventricle (LV) (pump failure) caused by AMI* or arrhythmias
28
cardiogenic shock management
MI: revascularize (CABG) arrhythmia: achieve sinus rhythm advanced: LVADs or ECMO
29
distributive shock
vasodilation aka septic shock
30
obstructive shock
decrease in LV SV or increase in LV outflow obstruction from thrombolytic therapy
31
fluid therapy
crystalloid 30 mL/kg over 15-30 min then 10 mL/kg boluses cardiogenic shock: 100-200 mL boluses
32
pharmacotherapy of shock pearl
initiate vasoactive agents when MAP remains <65 mmHg despite fluid admin
33
norepinephrine
-alpha adrenergic agonist -↑ MAP via peripheral vasoconstriction
34
epinephrine
-alpha and beta adrenergic agonist -secondary choice for sepsis -may increase aerobic lactate production -useful for anaphylactic shock
35
dopamine
-dose-dependent PK -for hypotensive patients with depressed cardiac function -AE: tachycardia, arrhythmogenesis
36
phenylephrine
-alpha-1 adrenergic agonist -only recommended if CO in high and BP is low -"reflex bradycardia"
37
dobutamine
-inotrope -beta-1 -added when CO or Svo2 goals have not been achieved
38
vasopressin
-Antidiuretic hormone (ADH) -goal is to reduce concurrent vasopressor doses
39
angiotensin II (giapreza)
-indicated for septic shock -risk for thromboembolism