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BCM215 > hémochromatose > Flashcards

hémochromatose Flashcards

1
Q

Hémochromatoses

A

maladie génétique conduisant à une surcharge systémique en fer

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2
Q

population la plus tout toucher par l’hémochromatose

A

Caucasienne

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3
Q

Fer indispensable pour…

A

le transport O2
la respiration cellulaire
la synthèse ADN
catalyse conversion de H2O2 en radicaux libres (que si surcharge de fer)

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4
Q

fer éliminé par

A

La desquamations des cellules cutanées et intestinal, et les menstruations

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5
Q

Stockage fer

A

Ferritines

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6
Q

contrôle absorption du fer

A

Hepcidine

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7
Q

Transporteur du fer

A

ferroportine et la transferrine

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8
Q
A
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9
Q

hémochromatose

A

maladie génétique conduisant à une surcharge systémique en fer

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10
Q

population la plus touchée par hémochromatose

A

caucasienne

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11
Q

fer indispensable pour….

A

le transport O2, la respiration cellulaire
synthèse ADN
Catalyse convertion H202 en radicaux libres ( que si surcharge de fer)

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12
Q

fer éliminé par

A

La desquamation des cellules cutanées et intestinal et les menstruation

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13
Q

Stockage du fer au niveau …

A

ferritines

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14
Q

Transporteur fer

A

ferroportine et transferrine

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15
Q

contrôle absorption du fer par …

A

Hepcidine

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16
Q

contrôle hepcidine

A

gène HAMP

17
Q

Hepcidine est

A

une hormone de 25 acide aminées synthétiser par le foie

18
Q

dépistage surcharge en fer

A

calcule saturation de la transferrine

19
Q

Recyclage fer

A

macrophage

20
Q

hémochromatose génétique plus fréquente

A

mutation C282Y

21
Q

Hémochromatose classe 1 cause :

A

mutation du gène HFE

22
Q

hyper ferritinémie

A

surcharge en fer
syndrome inflammatoire ou syndrome métabolique

BCM215 (5 decks)

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