Hemo exam 6

Question 1

platelet maturation

Answer 1

PPSC, megakaryoblast, promegakaryocyte, megakaryocyte

Question 2

what is a platelet

Answer 2

cytoplasmic fragments of a megakaryocyte

Question 3

platelets are produced by

Answer 3

budding and cytoplasic demarkation

Question 4

which platelet replication is found in unhealthy animals

Answer 4

cytoplasmic demarkation

Question 5

stimulus for platelets?

Answer 5

thrombopoitein (TPO)

Question 6

TPO is released at _ rate

Answer 6

steady

Question 7

TPO binds to the

Answer 7

platelets

Question 8

unbound TPO is called

Answer 8

free thrombopoietin

Question 9

free thrombopoietin causes

Answer 9

bone marrow to produce and release more platelets

Question 10

what is the stimulus for platelet production

Answer 10

free TPO

Question 11

3 tests to evaluation platelets

Answer 11

platelet count, platelet morph, platelet estimate

Question 12

rare term in vet med

Answer 12

thrombocytosis

Question 13

norm platelet count cats and dogs

Answer 13

200,000-500,000

Question 14

Goal of hemostasis

Answer 14

maintain blood within vessels without clotting

Question 15

for primary hemostasis must have

Answer 15

exposure to subendothelium, basement membrane and collagen

Question 16

2 parts of primary hemostasis

Answer 16

vascular and platelet plug

Question 17

2 parts of vascular part

Answer 17

production of VIII and von Willebrands , vascular spasm

Question 18

where is VIII and von Willebrand produced>

Answer 18

by endothelial cells and platelets

Question 19

platelet plug also known as

Answer 19

viscous metamorphosis

Question 20

3 parts to platelet plug

Answer 20

adhesion, aggregation, secretion

Question 21

adhesion requires

Answer 21

vWB factor

Question 22

platelets adhere to

Answer 22

subendothelial collagen

Question 23

aggregation is when the platelets

Answer 23

stick to eachother

Question 24

during platelet plug what is secreted

Answer 24

TXA, PS3, vWB factor, VIII, Plt derived growth factor

Question 25

TXA stands for

Answer 25

thromboxan

Question 26

TXA causes

Answer 26

vacoconstriction and further plt aggregation

Question 27

PF3 does what

Answer 27

stimulates and amplifies coag cascade (secondary hemostasis)

Question 28

vWB and VII does what

Answer 28

tells secondary to hurry

Question 29

Plt derived growth factor does what

Answer 29

neovascularization

Question 30

secondary pathways

Answer 30

extrinsic, intrinsic, common

Question 31

extrinsic pathways requires

Answer 31

tissue thromboplastin to come into contact with VII

Question 32

tissue thromboplastin released from

Answer 32

injured cells of any kind

Question 33

intrinsic pathway requires what factors

Answer 33

XII, XI, IX, VIII

Question 34

intrinsic pathway factors need to come in contact with

Answer 34

collagen, endotoxin platelet products, negatively charged substances to comes activated

Question 35

both intrinsic and extrinsic produce

Answer 35

prothrombinase

Question 36

what happens in common pathway

Answer 36

prothrombinase causes prothrombin to become thrombin, thrombin tells fibrinogen to become fibrin–>fibrin clot

Question 37

liver produces all clotting factors except

Answer 37

VIII and vWB

Question 38

vitamin K dependent factors

Answer 38

II, VII, IX, X

Question 39

goal of fibrinolysis

Answer 39

reshape clot, prevent over stimulation of clot formation

Question 40

plasminogen is activated into plasmin when

Answer 40

it binds to fibrin

Question 41

plasminogen is present in

Answer 41

plasma and platelet membrane

Question 42

unbound plasmin is

Answer 42

inactivated

Question 43

bound plasmin does what

Answer 43

hydrolyzes fibrin producing FDPs

Question 44

FDP stains for

Answer 44

fibrin degradation product

Question 45

FDPs and FSP activity?

Answer 45

anticoagulant

Question 46

FDP FSP function

Answer 46

block thrombin, inhibit platelets

Question 47

FDP is cleared by

Answer 47

liver