HemePharm Flashcards
Recombinant EPO agents
Epoetin
Darbepoetin
Direct thrombin inhib
+ reversal agent
BAD
Bivalirudin
Argatroban
Dabigatran // Idarucizumab
- PCC n/or antifibrinolytics: Tranexamic acid
LMWH
Enofaparin
Dalteparin
Fondaparinaux (Xa)
INR
Warfarin control
pt PT / control PT
N = 1
Factor Xa inhib
Reversal
Apixaban
Rivaroxaban
Andexanet alfa
Thrombolytics
Reversal
Alteplase, tPA
Reteplase, rPA
Streptokinase
Tenecteplase, TNK-tPA
- Antifibrinolytics: Aminocaproic acid, Tranexamic acid
- Platelet transfusion
- Factor correction: cryoppt, FFP, PCC
ADP receptor inhib
Parasugrel
Clopidogrel
Ticlopidine
Ticagrelor
Mitosis inhib
Microtubule inhib:
Paclitaxel
Vincristine/Vinblastine
DNA synth inhib
Antimetabolites:
Azathioprine Cladribine Cytarabine 5-fluorouracil Hydroxyurea Methotrexate 6-mercaptopurine
DNA synth + G2 inhib
Topoisomerase inhib:
II: Etoposide, Teniposide
I: Irinotecan, Topotecan
Nucleotide synth inhib
MTX,5-FU: ↓ thymidine synthesis
6-MP: ↓ de novo purine synthesis
Hydroxyurea: inhibits ribonucleotide reductase
Anti tumor Abx
Bleomycin
Dactinomycin
Anthracyclines: doxo/daunorubicin
Tx heparin-induced thrombocytopenia
Argatroban
AFib, venous thromboembolic Tx
Dabigatran
Inhibition in fibrinogen n GpIIb/IIIa receptors
Abciximab
G-CSF analog
Filagrastim
Methotrexate OD
Leucovorin
Used in combination w 5FU
Unfractioned vs LMWH
Both bind to Antithrombin III
Unfractioned : more molecules, longer chain, binds to factor Xa + thrombin to inactivate
LMWH: only inactivates Thrombin
Fibrin inhib
tPA
Plasminogen -tPA-> plasmin - breaks fibrin : thrombolysis
Clot specific
Bcl2 inhib
Venetoclax.
Inc caspases: inc cell death
CLL
Proteasome inhib
Bortezomib
Prevents destruction of ubiquitinated intracellular proteins
Multiple myeloma
Drugs preventing cancer cells from evading cytotoxic T cells
Abx against PD1 : Pembrolizumab
CTLA4
PolyADP ribose polymerase
Olaparib
Repair of SS DNA
Breast, ovarian prostrate ca in BRCA mutation+
MAB against CD20
Rituximab
CLL
