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Heme & Onco > HemePharm > Flashcards

HemePharm Flashcards

1
Q

Recombinant EPO agents

A

Epoetin

Darbepoetin

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2
Q

Direct thrombin inhib

+ reversal agent

A

BAD

Bivalirudin
Argatroban
Dabigatran // Idarucizumab

  • PCC n/or antifibrinolytics: Tranexamic acid
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3
Q

LMWH

A

Enofaparin
Dalteparin
Fondaparinaux (Xa)

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4
Q

INR

A

Warfarin control

pt PT / control PT

N = 1

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5
Q

Factor Xa inhib

Reversal

A

Apixaban
Rivaroxaban

Andexanet alfa

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6
Q

Thrombolytics

Reversal

A

Alteplase, tPA
Reteplase, rPA
Streptokinase
Tenecteplase, TNK-tPA

  1. Antifibrinolytics: Aminocaproic acid, Tranexamic acid
  2. Platelet transfusion
  3. Factor correction: cryoppt, FFP, PCC
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7
Q

ADP receptor inhib

A

Parasugrel
Clopidogrel
Ticlopidine
Ticagrelor

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8
Q

Mitosis inhib

A

Microtubule inhib:
Paclitaxel
Vincristine/Vinblastine

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9
Q

DNA synth inhib

A

Antimetabolites:

Azathioprine 
Cladribine 
Cytarabine 
5-fluorouracil 
Hydroxyurea 
Methotrexate 
6-mercaptopurine
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10
Q

DNA synth + G2 inhib

A

Topoisomerase inhib:

II: Etoposide, Teniposide

I: Irinotecan, Topotecan

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11
Q

Nucleotide synth inhib

A

MTX,5-FU: ↓ thymidine synthesis

6-MP: ↓ de novo purine synthesis

Hydroxyurea: inhibits ribonucleotide reductase

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12
Q

Anti tumor Abx

A

Bleomycin
Dactinomycin
Anthracyclines: doxo/daunorubicin

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13
Q

Tx heparin-induced thrombocytopenia

A

Argatroban

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14
Q

AFib, venous thromboembolic Tx

A

Dabigatran

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15
Q

Inhibition in fibrinogen n GpIIb/IIIa receptors

A

Abciximab

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16
Q

G-CSF analog

A

Filagrastim

17
Q

Methotrexate OD

A

Leucovorin

Used in combination w 5FU

18
Q

Unfractioned vs LMWH

A

Both bind to Antithrombin III

Unfractioned : more molecules, longer chain, binds to factor Xa + thrombin to inactivate

LMWH: only inactivates Thrombin

19
Q

Fibrin inhib

A

tPA

Plasminogen -tPA-> plasmin - breaks fibrin : thrombolysis

Clot specific

20
Q

Bcl2 inhib

A

Venetoclax.

Inc caspases: inc cell death

CLL

21
Q

Proteasome inhib

A

Bortezomib

Prevents destruction of ubiquitinated intracellular proteins

Multiple myeloma

22
Q

Drugs preventing cancer cells from evading cytotoxic T cells

A

Abx against PD1 : Pembrolizumab

CTLA4

23
Q

PolyADP ribose polymerase

A

Olaparib

Repair of SS DNA

Breast, ovarian prostrate ca in BRCA mutation+

24
Q

MAB against CD20

A

Rituximab

CLL

25
Q

Complications of factor VIII replacement/ conc from plasma

A

Formation of inhibitor alloabx against factor VIII

  • Emicizumab used instead
26
Q

Heparin bridge MOA

A

Heparin used w warfarin since warfarin inhibits synth of NEW Vit K dep clotting factors which takes about 3days d/t long t1/2 of factor II to completely deplete

Heme & Onco (5 decks)

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