Hemepath

Question 1

Kikuchi-Fujimoto lymphadenitis

Answer 1

Dendritic cells CD 123

Question 2

How do most B-cell lymphomas present

Answer 2

Lymphadenopathy (2/3)

Question 3

Which types of lymphomas involve the marrow at presentation? what %?

Answer 3

Low grade lymphomas; 40% involve marrow at presentation

Question 4

Do high grade lymphomas (DLBCL and Burkitts) typically affect older or younger patients

Answer 4

Younger

Question 5

What is the most common B-cell lymphoma of the Western world

Answer 5

CLL/SLL

Question 6

What is a common clinical finding in CLL

Answer 6

Hypogammaglobulinemia (50%)

Question 7

What disorder gives smudge cells? what causes it?

Answer 7

CLL; EDTA

Question 8

What are the BM patterns for CLL? Which one has the worst prognosis?

Answer 8

Nodular, interstital, diffuse; diffuse has worst prognosis

Question 9

IHC: CD19, CD20 (dim), CD23, CD5, sIg (dim), CD43, CD79a, CD11c (dim/variable)
Negative: FMC-7, CD10, BCL1, BCL6

Answer 9

CLL/SLL

Question 10

What are the 2 prognostic markers of CLL/SLL? What is the IgVH status?

Answer 10

CD38+ (over 30%) and ZAP-70+ (over 20%); when IgVH is unmutated = worse prognosis

Question 11

Polyclonal population of CD19,CD5+ can be seen in what disorders

Answer 11

HepC; status-post BMT; and autoimmune disease esp rheumatoid arthritis

Question 12

What is the name of the transformation of CLL to DLBCL?

Answer 12

Richter’s transformation

Question 13

Lymphoma involving gastrointestinal tract as lymphomatous polyposis

Answer 13

Mantel cell lymphoma

Question 14

Lymphoma with node effaced with small lymphocytes with irregular nuclear contours, NO proliferation centers

Answer 14

Mantle cell lymphoma

Question 15

IHC: CD19, CD20 bright, CD22, FMC-7, CD5, sIg(bright), CD43, BCL1(cyclinD1/Prad1)
Negative: CD23, CD11c, CD10

Answer 15

Mantle cell lymphoma

Question 16

Molecular characteristic of MCL (mantle cell)

Answer 16

t(11;14)

CCND1(BCL1)/IgH fusion

Question 17

What is the most important prognostic factor in mantle cell lymphoma

Answer 17

Mitotic rate

Question 18

What are the 2 cell types in follicular lymphoma and what is their significance for grading FL

Answer 18

Centrocytes and centroblasts
Grading depends on the number of centroblasts found per HPF.
Low grade (1 and 2): 0-6 and 6-15 centrocytes/HPF
High grade (3): greater than 15/HPF
3A: some residual centrocytes
3B: no residual centrocytes

Question 19

What is the common BM finding in follicular lymphoma

Answer 19

Paratrabecular aggregates

Question 20

IHC: CD19, CD20, FMC-7, CD22, CD23, CD10, sIg(bright), BLC2, BCL6
Negative: CD5, C43, and CD11c

Answer 20

Follicular lymphoma

Question 21

Supratentoral neoplasm that mimics GBM and shows perivascular lymphocyte cuffs

Answer 21

Primary CNS lymphoma

Question 22

What is on the differential for TCRBCL? what stain will help differentiate

Answer 22

Lymphocyte rich CHL or NLPHL (stains CD15 and Cd30 will not help to differentiate NLPHL)
TCRBCL is negative for both CD15 and CD30, so that RO the LR-CHL

Question 23

t(8;14) t(2;8) t(8;22)…what is the important gene

Answer 23

Burkitt lymphoma; cMYC on xsm 8

Question 24

Plasma cell myeloma FISH finding with longest survival

Answer 24

t(11;14) only

Question 25

Plasma cell myeloma FISH finding with shortest survival

Answer 25

t(4;14), t(14;16), or 17p13.1 deletion

Question 26

Plasma cell myeloma FISH finding with intermediate survival

Answer 26

13q14 deletion only