Hemepath Flashcards
Kikuchi-Fujimoto lymphadenitis
Dendritic cells CD 123
How do most B-cell lymphomas present
Lymphadenopathy (2/3)
Which types of lymphomas involve the marrow at presentation? what %?
Low grade lymphomas; 40% involve marrow at presentation
Do high grade lymphomas (DLBCL and Burkitts) typically affect older or younger patients
Younger
What is the most common B-cell lymphoma of the Western world
CLL/SLL
What is a common clinical finding in CLL
Hypogammaglobulinemia (50%)
What disorder gives smudge cells? what causes it?
CLL; EDTA
What are the BM patterns for CLL? Which one has the worst prognosis?
Nodular, interstital, diffuse; diffuse has worst prognosis
IHC: CD19, CD20 (dim), CD23, CD5, sIg (dim), CD43, CD79a, CD11c (dim/variable)
Negative: FMC-7, CD10, BCL1, BCL6
CLL/SLL
What are the 2 prognostic markers of CLL/SLL? What is the IgVH status?
CD38+ (over 30%) and ZAP-70+ (over 20%); when IgVH is unmutated = worse prognosis
Polyclonal population of CD19,CD5+ can be seen in what disorders
HepC; status-post BMT; and autoimmune disease esp rheumatoid arthritis
What is the name of the transformation of CLL to DLBCL?
Richter’s transformation
Lymphoma involving gastrointestinal tract as lymphomatous polyposis
Mantel cell lymphoma
Lymphoma with node effaced with small lymphocytes with irregular nuclear contours, NO proliferation centers
Mantle cell lymphoma
IHC: CD19, CD20 bright, CD22, FMC-7, CD5, sIg(bright), CD43, BCL1(cyclinD1/Prad1)
Negative: CD23, CD11c, CD10
Mantle cell lymphoma
Molecular characteristic of MCL (mantle cell)
t(11;14)
CCND1(BCL1)/IgH fusion
What is the most important prognostic factor in mantle cell lymphoma
Mitotic rate
What are the 2 cell types in follicular lymphoma and what is their significance for grading FL
Centrocytes and centroblasts
Grading depends on the number of centroblasts found per HPF.
Low grade (1 and 2): 0-6 and 6-15 centrocytes/HPF
High grade (3): greater than 15/HPF
3A: some residual centrocytes
3B: no residual centrocytes
What is the common BM finding in follicular lymphoma
Paratrabecular aggregates
IHC: CD19, CD20, FMC-7, CD22, CD23, CD10, sIg(bright), BLC2, BCL6
Negative: CD5, C43, and CD11c
Follicular lymphoma
Supratentoral neoplasm that mimics GBM and shows perivascular lymphocyte cuffs
Primary CNS lymphoma
What is on the differential for TCRBCL? what stain will help differentiate
Lymphocyte rich CHL or NLPHL (stains CD15 and Cd30 will not help to differentiate NLPHL)
TCRBCL is negative for both CD15 and CD30, so that RO the LR-CHL
t(8;14) t(2;8) t(8;22)…what is the important gene
Burkitt lymphoma; cMYC on xsm 8
Plasma cell myeloma FISH finding with longest survival
t(11;14) only
