HemeOnc

Question 1

What is the Mentzer index?

Answer 1

MCV/RBC count : if >13, think iron-deficiency anemia

Question 2

How long after normal values to continue iron supplements?

Answer 2

3-6 months

Question 3

What are iron, TIBC and ferritin in Iron Deficiency Anemia?

Answer 3

Iron, ferritin down; TIBC up

Question 4

What are iron, TIBC and ferritin in sideroblastic anemia?

Answer 4

Iron, ferritin up; TIBC down (smear - basophilic stippling)

Question 5

What are iron, TIBC and ferritin in thalassemia?

Answer 5

All normal to elevated. Increased RBC count!

Question 6

What are iron, TIBC and ferritin in anemia of chronic disease?

Answer 6

Iron up; TIBC and ferritin normal or down

Question 7

Possible etiologies of sideroblastic anemia?

Answer 7

LEAD poisoning, chronic etoh use, TB drugs, chloramphenicol (lead, lungs, liquor)

Question 8

What should be given to patietns with anemia of chronic disease?

Answer 8

epogen (erythropoietin)

Question 9

Mentzer score of <13 - ddx? How to differentiate?

Answer 9

Iron deficiency or thalassemia. IronDef should respond to supp. iron.

Question 10

Next step when thalassemia is suspected?

Answer 10

Hemoglobin electrophoresis

Question 11

Features of b-thalassemia?

Answer 11

BETA-THAL-D (BasStip, ExcessIron, Transplant, hbA decreased, Tower skull, HF, Anisocytosis, Liver&spleenLrage, Deforoxamine)

Question 12

Where are intrinsic factor receptors?

Answer 12

Terminal ileum

Question 13

MCV > 110 : what is #1 cause?

Answer 13

B12/folate deficiency

Question 14

Hypersegmented neutrophils - ddx?

Answer 14

megaloblastic anemia

Question 15

Causes of normal anemia?

Answer 15

Blood loss (acute), hemolysis or decreased production

Question 16

What breakdown makes urine dark (specific)?

Answer 16

unconjugated bilirubin

Question 17

Normal anemia - how to check for hemolysis?

Answer 17

LDH, retic. count, unconj. bili (all increased); haptoglobin (down)