Heme/Onco

Question 1

major basic protein

Answer 1

eosinophils

Question 2

basophil contents

Answer 2

heparin, histamine, leukotrienes

Question 3

anemia of unknown origin

Answer 3

order retic count

-elevated with blood loss/hemolysis

Question 4

Hb H

Answer 4

3 globin chain - a-thal

form B tetramers high affinity O2

Question 5

Hb barts

Answer 5

3 globin chain - a-thal

gamma-tetramers

risk - hydrops fetalis, intrauterine fetal demise

higher affinity for O2 - gamma tetramer

Question 6

warm vs. cold agglutinin

Answer 6

2 forms of autoimmune hemolytic anemia

warm - IgG - chronic disease and drug

cold - IgM - acute - mycoplasma and mono infection

Question 7

sickle cell mutation

Answer 7

AA replace ment - glutamine with valine

Hb B chain

Question 8

deficient vWF

Answer 8

impaired platelet adhesion

Question 9

pyogenic infection, low platelet, eczema

Answer 9

wiskott aldrich syndrome

X-linked recessive

low IgM

Question 10

selective igA deficiency

Answer 10

defect isotype switching

recurrent sinus and lung infection

milk allergy, diarrhea

Question 11

rheumatoid

Answer 11

DR4

Question 12

sjogren

Answer 12

DR3

Question 13

DM I

Answer 13

DR3, DR4

Question 14

arthus rxn

Answer 14

type III HS

Ab complex foreign proteins - cutaneous vasculitis and local necrosis

Question 15

imatinib

Answer 15

tx CML - BCR-ABL tyr kinase

Question 16

MC type hodgkins

Answer 16

nodular sclerosing

Question 17

age of hodgkins

Answer 17

bimodal

Question 18

acute vasc rejection

Answer 18

Abs to donor antigen

Question 19

acute cellular rejection

Answer 19

cell-mediated - CD4 and CD8 attack donor

Question 20

graft vs. host disease

Answer 20

donor lymphocyte - vs. host cells

with bone marrow transplant

Question 21

anticoag in bood

Answer 21

citrate

Question 22

cryoprecipitate

Answer 22

has factor 8, 13, fibrinogen, vWF