Heme/Onc Tx Flashcards
AML Induction Therapy
3 days of an Anthracycline + 7 days of cytarabine
AML Consolidation Chemo
3-4 cycles of cytarabine high dose over 5 days in conjuction with etoposide, daunomycin or idarubicin
ALL Induction Therapy (Philadelphia chromosome)
Gleevec (imatinib)
ALL Induction Therapy
Oncovin® (vincristine), Elspar® (L-asparaginase) or Oncaspar® (peg-L-asparaginase), and an anthracycline such as Adriamycin® (doxorubicin)
Older Pt with ALL
Hyper-CVAD (cyclophosphamide, vincristine, doxorubicin, dexamethasone)
ALL Induction Therapy Children
administering three drugs: Oncovin® (vincristine), prednisone or dexamethasone, and Elspar® (L-asparaginase) or Oncaspar® (PEG-L-asparaginase).
CLL Early Stage (Rai 0-II; Binet A)
NOTHING unless high risk/symptomatic
CLL Symptomatic single chemotherapy agent
Leukeran® (chlorambucil) and Fludara® (fludarabine), Rituxan® (rituximab), Campath® (alemtuzumab), and Treanda® (bendamustine).
CLL Symptomatic multitherapy Tx
Fludara; Cytoxan; Rituxan; Mitoxantrone; Campath
Fludara plus Cytoxan (FC);
Fludara, Cytoxan, and Rituxan (FCR);
Fludara, Cytoxan and Mitoxantrone (FCM) with or without Rituxan;
Fludara, Cytoxan, and Campath (FCC)
Cytoxan, Fludara, Campath and Rituxan (CFAR)
Nipent, Cytoxan and Rituxan (PCR)
CLL supportive care
Intravenous Immunoglobulin cotrimoxazole----Pneumocystis carinii valganciclovir-----Cytomegalovirus Systemic/broad spec antibiotics----Bacterial Infections Antifungals----PRN for fungal infections Neulasta or Neupogen-----Neutropenia Epogen----Anemia
CML Chronic phase
Gleevec or Tasigna
CML Accelerated phase (after Gleevec failure)
Tasigna or Sprycel
CML Blastic phase (after Gleevec failure)
Sprycel or Nilotinib
Anal CA Tx
surgery, radiation therapy, or chemotherapy
Anemia Tx
Dietary/supplements: B12, folic acid, iron, and vitamin C
Medication: vitamin B12 injections, folic acid pills, intravenous iron or oral iron pills, antibiotics, or hormones.
Blood transfusions, or surgery.
Barrett’s Esophagus Tx
Anti-reflux medication—Without dysplasia
Anti-reflux medication possibly photodynamic/laser—-Low-grade dysplasia
Esophagectomy—-High-grade dysplasia
Esophageal CA Stage 0-II
Esophagectomy
Esophageal CA Stage III
Neoadjuvant chemotherapy and radiation followed by surgery
Esophageal CA Stage IV
Multiple palliative measures, chemotherapy, radiation, surgery
Esophageal CA chemotherapy Tx
Fluorouracil and Mutamycin®
Bladder CA Stage 0-I
Transurethral Resection (TUR); Bladder Instillation of Bacille Calmette-Guérin (BCG)
Bladder CA Stage II-III
Cystectomy; Neoadjuvant Chemo+Cystectomy
Bladder CA Stage IV
Palliative chemotherapy +/- surgery
Bladder CA Chemo
GC: Gemzar® (gemcitabine) and cisplatin.
MVAC: methotrexate, vinblastine, doxorubicin, and cisplatin.
Brain CA
Surgery and or External Beam Radiation Therapy (EBRT)
Breast CA chemo
Cyclophosphamide, doxorubicin, fluorouracil, methotrexate, Taxotere
CMF: cyclophosphamide, methotrexate and fluorouracil
CAF: cyclophosphamide, doxorubicin, and fluorouracil
AC: doxorubicin and cyclophosphamide
TAC: Taxotere, doxorubicin, cyclophosphamide
What adjuvant to Stage II-IV Breast CA can be used?
Taxanes (Taxotere; Taxol)
Breast CA Adjuvant
Taxanes
Estrogen modulator (Tamoxifen, Aromatase inhibitors)
HER2 (Herceptin)
Premenopausal Estrogen modulation
Tamoxifen
Postmenopausal Estrogen modulation
Aromatase inhibitor +/- Tamoxifen
Cervical CA Stage 0-1 Tx
Total hysterectomy or conization surgery
Cervical CA Stage 2-4 Tx
Chemo/Radiation
Cervical CA Chemo
Platinol®, 5-fluorouracil
Colon CA Stage I-III
Surgery + Adjuvant Chemo
Colon CA Stage IV
Chemo + Avastin
Colon CA Chemo Adjuvant
FOLFOX (LV/5-fluorouracil + Eloxatin (oxaliplatin)
CAPEOX (Xeloda (capecitabine) + Eloxatin
Xeloda
Colon CA Chemo Stage IV
FOLFOX (LV/5-fluorouracil + Eloxatin (oxaliplatin)
CAPEOX (Xeloda (capecitabine) + Eloxatin)
FOLFIRI (LV/5-fluorouracil + Camptosar (irinotecan)
FOLFOXIRI (LV/5-fluorouracil + Camptosar + Eloxatin
Essential Thrombocytopenia
Low-dose-aspirin; Hydroxyurea
Myelofibrosis
Jakafi Androgens Immunomodulators Hydroxyurea Blood Transfusions Splenectomy
Polycythemia Vera
Phlebotomy
Low-dose-aspirin
Hydroxyurea
Ewing Sarcoma Localized
Surgery, Radiation, Chemo
Ewing Sarcoma Metastatic
Chemo
Ewing Sarcoma Chemo
vincristine, actinomycin D, cyclophosphamide, and doxorubicin with alternating cycles of ifosfamide and etoposide
