Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Heme/onc R&M > Heme/onc: random memorization > Flashcards

Heme/onc: random memorization Flashcards

1
Q

Life-span of platelets?

A

8-10 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What fraction of platelet pool is stored in spleen?

A

1/3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What do platelet dense granules contain?

A

ADP

Calcium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What do platelet alpha granules contain?

A

vWF

Fibrinogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What’s the vWF receptor?

A

GpIb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What’s the fibrinogen receptor?

A

GpIIb/IIIa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What do pmn specific granules contain?

A

ALP
Collagenase
Lysozyme
Lactoferrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What do pmn azurophilic granules (lysosomes) contain?

A

Proteinases
Acid phosphatase
Myeloperoxidase
Beta-glucuronidase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

CD14 is a cell surface marker for what cell?

A

Macrophages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What kind of nucleus do eosinophils have?

A

Bilobed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Eosinophils make 2 major substances that help limit rxns after mast cell degranulation. What are they?

A

Histaminase

Arylsulfatase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What do basophils’ granules contain?

A

Hepatin
Histamine
Leukotrienes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Isolated basophilia can be a sign of what scary disease?

A

CML

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What 3 substances are released upon mast cell degranulation?

A

Histamine
Heparin
Eosinophilic chemotactic factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Eosin-5-maleimide binding test is used to screen for what hematologic disease?

A

Hereditary spherocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Why can patients with G6PD deficiency have increased bac/fungal infections?

A

Decreased glutathione interferes w/ normal fxns of MPO system, needed for clearance of bac/fungi.

17
Q

People with HbC defect have what very characteristic finding in their rbcs?

A

HbC crystals

18
Q

What is glutamic acid mutated to in HbC?

A

Lys

19
Q

Rx of PNH?

A

Eculizumab

20
Q

PNH has an increased risk of what kind of cancer?

A

Acute leukemias

21
Q

Sickle cell trait: where’s the only site of sickling (under normal conditions)?

A

Renal medulla

22
Q

MCC of death in sickle cell dz: adults?

A

Acute chest syndrome

23
Q

MCC of death in sickle cell dz: kids?

A

Infection w/ encapsulated organisms

24
Q

AutoAbs in ITP?

A

Anti-GpIIb/IIIa

25
Q

Prothrombin gene mutation causes a hypercoagulable state. Describe the actual mutation.

A

Mutation in 3’ UTR–> incr production of prothrombin

26
Q

What inherited disease would cause a diminished increase in PTT after heparin admin?

A

Antithrombin 3 deficiency

27
Q

Which step of protoporphyrin synth requires B6? Name reactants, products, and the enz.

A

Gly + succinyl CoA–> delta-ALA.

Enz: Delta-ALA synthase

28
Q

What’s the rate-limiting enz of protoporphyrin synth?

A

Delta-ALA synthase

29
Q

Deficiency of ALA-synthase causes what disease?

A

X-linked sideroblastic anemia

30
Q

Deficiency of porphobilinogen deaminase causes what disease?

A

Acute intermittent porphyria

31
Q

Deficiency of uroporphyrinogen deaminase causes what disease?

A

Porphyria cutanea tarda

32
Q

Why is DDAVP helpful in vWD?

A

Releases stored vWF from the endothelium

33
Q

What could cause acquired antithrombin deficiency?

A

Renal failure or nephrotic syndrome

34
Q

How does leukocyte ALP differ in CML and leukemoid rxn?

A

Increased in leukemoid rxn; decreased in CML

35
Q

1 unit of packed RBCs should increase HCT by how much?

A

3%

36
Q

1 unit of platelets should increase platelet count by how much?

A

5000 platelets/ mm^3

37
Q

How can transfusion affect K levels?

A

Can cause hyperkalemia due to lysis of RBCs in old blood

38
Q

What translocation is seen in mantle cell lymphoma? What gene does this activate?

A

t(11;14), cyclin D1

39
Q

The mixed cellularity type of Hodgkin’s lymphoma can characteristically release a certain IL, which attracts a specific set of wbcs. Name the IL and wbc.

A

IL-5, eosinophils

Heme/onc R&M (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions