Heme/Onc FA Flashcards by Caitriona McGovern

Auer rod

AML

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C-myc

Burkitt lymphoma

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t(8;14)

Burkitt lymphoma

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Low hemoglobin + thrombocytopenia + absent hematopoietic cells in BM

Aplastic anemia

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osmotic fragility test

hereditary spherocytosis

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increased MCHC

hereditary spherocytosis

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liver disease

factor Vii deficiency

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Heinz bodies

G6PD

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Bite cells

G6PD

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Kozak consensus sequence mutation

thalassemia intermedia

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acanthocyte (spur cell)

liver disease, abetalipoproteinemia

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basophilic stippling

thalassemias, anemia of chronic dz., lead poisoning (“baste the ox TAiL)

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macroovalocyte

megaloblastic anemia, marrow failure

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ringed sideroblasts

sideroblastic anemia

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schistocyte

DIC, TTP, HUS, traumatic hemolysis (mech damage)

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spherocyte

hereditary spherocytosis, autoimmune hemolysis

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teardrop cell

myelofibrosis

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target cell

HbC disease, asplenia, liver dz., thalassemia

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Howell-Jowell bodies

functional hyposplenia or asplenia, or after naphthalene (mothball) ingestion

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Iron deficiency anemia + esophageal webs + atrophic glossitis

Plummer-Vinson syndrome

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CD55/59 negative RBCs on flow cytometry

PNH

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Warm agglutinin antibody

IgG

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Cold agglutinin antibody

IgM

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lead poisoning affected enzyme

ferrochelatase, ALAD

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acute intermittent porphyria affected enzyme

porphobilinogen deaminase

porphyria cutanea tarda affected enzyme

uroporphyrinogen decarboxylase

GPIb defect

Bernard-Soulier syndrome

GPIIb/IIIa defect

Glanzmann's thrombobasthenia

ristocetin

vWF disease

vWF treatment

desmopressin

sickle cell anemia treatment

hydroxyurea, BMT

sideroblastic anemia treatment

pyridoxine (B6)

inhibitors of ADP-induced expression of GpIIb/IIIa

ticlopidine, clopidogrel

direct inhibitor of GPIIb/IIIa

abciximab

vWF receptor

GPIb

Fibrinogen receptor

GPIIb/IIIa

drug that prevents mast cell degranulation

cromolyn sodium (used for asthma prophylaxis)

elliptocyte

hereditary elliptocytosis

chipped paint

lead poisoning

Adult lead poisoning treatment

Dimercaprol, EDTA

Kid lead poisoning treatment

Succimer ("It sucks to be a kid who eats lead")

orotic aciduria treatment

urinidine monophophate

PNH treatment

eculizumab

Glutamic acid to lysine mutation at residue 6 in beta globin

HbC

hemolytic anemia in newborn

pyruvate kinase deficiency

tea-colored urine

porphyria cutanea tarda

port wine-colored urine

acute intermittent porphyria

acute intermittent porphyria treatment

glucose and heme (inhibit ALA synthase)

CD30+/CD15+

RS cells (Hodgkin lymphoma)

binucleate or bilobed B cell (two halves are mirror images)

RS cells

t(9,22)

CML (bcr-abl)

t(8;14)

Burkitt's lymphoma (c-myc)

t(11;14)

mantle cell lymphoma (Cyclin D1)

t(14;18)

follicular lymphoma (bcl-2_

t(15;17)

M3 type of AML (responsive to all-trans retinoid acid)

CML (bcr-abl) translocation

t(9;22)

Burkitt lymphoma translocation

t(8;14)

mantle cell lymphoma translocation

t(11;14)

follicular lymphoma translocation

t(14;18)

APL (AML) translocation

t(15;17)

Birbeck granules on EM S-100+, CD1a+

langerhans cell histocytosis

What does c-Myc do?

Transcription activator that controls cell proliferation, differentiation, and apoptosis

Epidermal growth factor receptor that has intracellular tyrosine kinase activity and is present in up to 30% of invasive breast cancers

HER2/neu oncogene

Adult brain tumor that arises within the cerebral hemispheres and frequently crosses the midline; foci of necrosis and hemorrhage are seen on macroscopic examination

Glioblastoma multiforme

What are the three most common primary brain tumors in adults?

Glioblastoma multiforme (astrocytoma), meningioma, acoustic neuroma (schwannoma)

Proliferation signals --> CDK4 --> hyperphosphorylates Rb protein (inactivating it) -->

cells transition unchecked from G1 to S phase

Integrin-mediated adhesion of cells to basement membrane and ECM involves binding to:

fibronectin, collagen, and laminin

Intracellular enzyme involved in metabolism of pro-carcinogens that makes ppl more likely to get lung cancer

Microsomal monooxygenase

waxing and waning LAD

follicular lymphoma

what mediates paraneoplastic cachexia?

TNF-alpha

Cerebellar tumor in a child

pilocytic astrocytoma or medulloblastoma