heme onc buzzwords

Question 1

increased MCHC

Answer 1

hereditary spherocytosis

Question 2

treatment for hereditary spherocytosis

Answer 2

splenectomy

Question 3

G6PD transmission

Answer 3

X linked recessive

Question 4

heinz bodies

Answer 4

G6PD

Question 5

CD55/59 negative

Answer 5

Paroxysmal nocturnal hemoglobinuria

Question 6

PNH patients have increased chance of what

Answer 6

10% chance of AML

Question 7

osmotic fragility test +

Answer 7

hereditary spherocytosis

Question 8

howell jolly bodies

Answer 8

autosplenectomy (or anything where there is no spleen), seen with sickle cell

Question 9

HbC crystals

Answer 9

hemoglobin C

Question 10

positive sucrose test

Answer 10

PNH

Question 11

acidified serum test

Answer 11

PNH

Question 12

cause of death in PNH

Answer 12

thrombosis of hepatic, portal, or cerebral veins (destroyed platelets activate coagulation cascade)

Question 13

metabisulfite screen positive

Answer 13

sickle cell trait and disease

Question 14

most common cause of death in sickle cell adults

Answer 14

acute chest syndrome

Question 15

most common cause of death in sickle cell children

Answer 15

infection with encapsulated organisms

Question 16

target cells

Answer 16

thalassemia/sickle cell

Question 17

decreased serum haptoglobin

Answer 17

intravascular hemolysis

Question 18

G6PD inheritance

Answer 18

x linked recessive

Question 19

most common enzymatic disorder of RBCa

Answer 19

G6PD deficiency

Question 20

hemolytic anemia in newborn

Answer 20

pyruvate kinase deficiency

Question 21

bite cells

Answer 21

G6PD deficiency

Question 22

when can you test a patients serum for G6PD?

Answer 22

after the acute episode resolves - otherwise all the enzyme-deficienct cells are lysed and you wont realize

Question 23

2 diseases you see in warm agglutanin

Answer 23

CLL and SLE

Question 24

schistocytes/helmet cells

Answer 24

microangiopathic hemolytic anemia