heme onc buzzwords Flashcards
increased MCHC
hereditary spherocytosis
treatment for hereditary spherocytosis
splenectomy
G6PD transmission
X linked recessive
heinz bodies
G6PD
CD55/59 negative
Paroxysmal nocturnal hemoglobinuria
PNH patients have increased chance of what
10% chance of AML
osmotic fragility test +
hereditary spherocytosis
howell jolly bodies
autosplenectomy (or anything where there is no spleen), seen with sickle cell
HbC crystals
hemoglobin C
positive sucrose test
PNH
acidified serum test
PNH
cause of death in PNH
thrombosis of hepatic, portal, or cerebral veins (destroyed platelets activate coagulation cascade)
metabisulfite screen positive
sickle cell trait and disease
most common cause of death in sickle cell adults
acute chest syndrome
most common cause of death in sickle cell children
infection with encapsulated organisms
target cells
thalassemia/sickle cell
decreased serum haptoglobin
intravascular hemolysis
G6PD inheritance
x linked recessive
most common enzymatic disorder of RBCa
G6PD deficiency
hemolytic anemia in newborn
pyruvate kinase deficiency
bite cells
G6PD deficiency
when can you test a patients serum for G6PD?
after the acute episode resolves - otherwise all the enzyme-deficienct cells are lysed and you wont realize
2 diseases you see in warm agglutanin
CLL and SLE
schistocytes/helmet cells
microangiopathic hemolytic anemia
