Heme/Onc

Question 1

What index can be used to differentiate between thalassemias and iron deficiency anemia?

Answer 1

Mentzer Index (MCV/RBC) 
> 13 in iron deficiency
< 13 in thalassemia

Question 2

Which vaccines must be provided prior to splenectomy?

Answer 2

Pneumococcal
H. Flu
Meningococcal

Question 3

What is the most common clinical manifestation of a sickle cell patient’s first pain crisis?

Answer 3

Dactylitis

Question 4

What is the triad of paroxysmal nocturnal hemoglobinuria?

Answer 4

Hemolytic anemia
Pancytopenia
Arterial/venous thromboses

Question 5

What is the treatment of PNH?

Answer 5

Eculizumab

Question 6

The incidence of what cancer is increased in individuals with sickle cell trait?

Answer 6

Renal medullary carcinoma

Question 7

Is cold agglutinin disease coombs positive or negative?

Answer 7

negative

Question 8

What is Kostmann syndrome?

Answer 8

Genetic syndrome associated with severe neutropenia < 200

Question 9

What is the syndrome?

FTT, steatorrhea, recurrent infections, neutropenia, metaphyseal dysotosis

Answer 9

Shwachman-Diamond

Question 10

What syndrome is characterized by hypereosinophilia, endocardial fibrosis and mural thrombi?

Answer 10

Loffler syndrome

Question 11

What is the difference in size of platelets in Wiskott Aldrich compared to ITP?

Answer 11

WAS–> small platelets, ITP are large platelets

Question 12

Which syndrome has thrombocytopenia, eczema and immunodeficiency?

Answer 12

Wiskott Aldrich

Question 13

What is the treatment for ITP?

Answer 13

• IVIG
• Corticosteroids
• Rh (D) antibody

Question 14

What factor is VWF associated with?

Answer 14

Factor 8

Question 15

What is the treatment of VWD?

Answer 15

DDAVP –> release of factor 8 and VWF

Question 16

Patient with fanconi anemia have increased risk of which malignancy?

Answer 16

AML

Question 17

What pathway does PT evaluate?

Answer 17

Extrinsic pathway- factor 7

Question 18

What is the treatment of Hemophilia A? What factor is missing?

Answer 18

Factor 8

DDAVP

Question 19

When is the highest incidence of Hodgkin Lymphoma?

Answer 19

Ages 15-19

Question 20

Which cancer involves the classic Reed-Sternberg cell appearance?

Answer 20

Hodgkin lymphoma

Question 21

Which type of cancer is increased in the following diagnoses: Ataxia-telangiectasia, Wiskott-Aldrich and HIV?

Answer 21

Non-hodgkin lymphoma

Question 22

What type of lymphoma is Burkitt lymphoma?

Answer 22

Non hodgkin lymphoma

Question 23

Which type of tumor is often associated with NF1?

Answer 23

Optic Gliomas

Question 24

What type of tumor is often associated with NF2?

Answer 24

Bilateral Vestibular Schwannomas

Question 25

What type of tumor is glioblastoma multiforme?

Answer 25

Astrocytoma

Question 26

What is a common complication of surgery for craniopharyngioma?

Answer 26

Diabetes insipidus

Question 27

What is the most common malignancy diagnosed during infancy?

Answer 27

Neuroblastoma

Question 28

In which diagnosis might you see increased VMA and HVA in urine?

Answer 28

Neuroblastoma

Question 29

What is the more common location of Ewing’s sarcoma and osteosarcoma in the bone?

Answer 29

Ewings- Diaphysis

Osteosarcoma- Metaphysis

Question 30

Which of the two sarcoma’s shows up as lytic on an xray: Ewings or osteosarcoma?

Answer 30

Ewing’s

Question 31

T/F: Pain in osteoid osteoma improves with NSAIDs

Answer 31

True